Ukwelashwa Kwamaseli e-NS7CAR-T Kubonisa Isithembiso Sokwelapha i-R/R T-ALL/LBL

Incwadi yakamuva ephephabhukwini i-Blood iveze ukunaka okukhulu emandleni okwelashwa kwamaseli e-NS7CAR-T ekwelapheni i-T-cell acute lymphoblastic leukemia (R/R T-ALL) ephinde yabuya noma engaphikisiwe kanye ne-T-cell lymphoblastic lymphoma (R/R T-LBL). Ucwaningo, olwenziwe njengesivivinyo somtholampilo sesigaba 1 (ClinicalTrials.gov: NCT04572308), luhlole ukuphepha nokusebenza kahle kwalokhu kwelashwa okusha.

Ukuhlolwa kwakuhlanganisa iziguli ezine-R/R T-ALL/LBL ezathola amaseli e-NS7CAR-T. Imiphumela ibonise ukuthi ukwelashwa kwe-NS7CAR-T akugcini nje ngokuphephile kodwa futhi kubonise umsebenzi omangalisayo wokulwa nomdlavuza. Iziguli ezelashwe ngamaseli e-NS7CAR-T zibonise izimpendulo ezibalulekile zezokwelapha, okuphakamisa amandla alolu hlobo lokwelapha njengethuluzi elinamandla lokulwa nalezi zinhlayiya eziyinselele.

Abacwaningi abasekela lolu cwaningo bahlanganisa ithimba lochwepheshe abavela eHebei Yanda Lu Daopei Hospital kanye naseHebei Senlang Biotechnology Co., Ltd. Okutholakele kwabo kubonisa ukuthi amaseli e-NS7CAR-T angakhiqizwa ngempumelelo ngaphandle kokuguqulwa okwengeziwe kwezakhi zofuzo ukuvimbela ukuvezwa kwe-CD7, ukwenza inqubo yokukhiqiza ibe lula futhi kuthuthukiswe ukusebenza kahle kokwelashwa.

Lokhu kuthuthuka ekwelashweni kwamaseli e-NS7CAR-T kuhambisana nemizamo eqhubekayo yokuthuthukisa ukwelashwa okusebenzayo kakhulu kwe-T-ALL kanye ne-T-LBL. Inkampani yethu nayo ithuthuka kulo mkhakha ngenkampani yethu eyingqayizivele Umkhiqizo we-CAR-T, esikholelwa ukuthi kuzohambisana nemiphumela ethembisayo ebonwe ngokwelashwa kwe-NS7CAR-T.

Imiphumela ekhuthazayo yalolu cwaningo ivula indlela yocwaningo olwengeziwe kanye nezivivinyo zemitholampilo ukuze kuqiniswe indima yamaseli e-NS7CAR-T ekwelapheni umdlavuza we-T-cell obuyela emuva noma ongasasebenzi. Njengoba idatha eyengeziwe itholakala, kunethemba lokuthi lokhu kwelashwa kuzoba yindlela ejwayelekile yeziguli ezilwa nalezi zifo ezinamandla.