Kurapa Masero eNS7CAR-T Kunoratidza Chipikirwa Chekurapa R/R T-ALL/LBL
Bhuku rakabudiswa munguva pfupi yapfuura mujenari reBlood rakaratidza kutarisisa kukuru kune mukana wekurapa kwemasero eNS7CAR-T pakurapa T-cell acute lymphoblastic leukemia (R/R T-ALL) yakadzoka kana kuti isingadzoreki uye T-cell lymphoblastic lymphoma (R/R T-LBL). Chidzidzo ichi, chakaitwa semuyedzo wekiriniki wechikamu chekutanga (ClinicalTrials.gov: NCT04572308), chakaongorora kuchengetedzeka uye kushanda kwekurapa uku kutsva.
Kuedzwa kwacho kwaisanganisira varwere vane R/R T-ALL/LBL vakagamuchira masero eNS7CAR-T. Zvakabuda zvakaratidza kuti kurapwa kweNS7CAR-T hakuna kungove kwakachengeteka chete asiwo kwakaratidza kushanda kunoshamisa kwekudzivirira bundu. Varwere vakarapwa nemasero eNS7CAR-T vakaratidza mhinduro dzakakosha dzekiriniki, zvichiratidza kugona kwekurapa uku sechishandiso chine simba kurwisa kenza idzi dzinonetsa.
Vaongorori vari shure kwechidzidzo ichi vanosanganisira timu yenyanzvi kubva kuHebei Yanda Lu Daopei Hospital neHebei Senlang Biotechnology Co., Ltd. Zvavakawana zvinoratidza kuti masero eNS7CAR-T anogona kugadzirwa zvakanaka pasina mamwe majini ekudzivirira kuburitswa kweCD7, zvichiita kuti maitiro ekugadzira ave nyore uye kuwedzera kushanda kwekurapa.
Kubudirira uku mukurapa kwemasero eNS7CAR-T kunoenderana nekuedza kuri kuitwa kugadzira mishonga inoshanda yeT-ALL neT-LBL. Kambani yedu iri kufambira mberiwo muchikamu ichi nemakambani edu ega ega. Chigadzirwa cheCAR-T, izvo zvatinotenda kuti zvichawedzera mhedzisiro inovimbisa yakaonekwa nekurapa kweNS7CAR-T.
Mhedzisiro inokurudzira yechidzidzo ichi inovhura nzira yekuenderera mberi nekutsvaga uye kuyedza kwekiriniki kusimbisa basa remasero eNS7CAR-T mukurapa kenza yeT-cell inodzoka kana kuti isingadzoreki. Sezvo ruzivo rwakawanda ruchiwanikwa, zvinotarisirwa kuti kurapwa uku kuchakurumidza kuva sarudzo yakajairika kune varwere vanorwara nezvirwere izvi zvine simba.