Hōʻike ka NS7CAR-T Cell Therapy i ka ʻōlelo hoʻohiki no ka mālama ʻana iā R/R T-ALL/LBL

Ua lawe mai kahi puke pai hou i ka puke pai Blood i ka nānā nui ʻana i ka hiki o ka lāʻau lapaʻau NS7CAR-T no ka mālama ʻana i ka leukemia lymphoblastic acute T-cell relapsed a refractory paha (R/R T-ALL) a me ka lymphoma lymphoblastic T-cell (R/R T-LBL). Ua loiloi ke aʻo ʻana, i mālama ʻia ma ke ʻano he hoʻokolohua lapaʻau pae 1 (ClinicalTrials.gov: NCT04572308), i ka palekana a me ka pono o kēia lāʻau lapaʻau hou.

Ua hoʻokomo pū ʻia ka hoʻokolohua i nā maʻi me R/R T-ALL/LBL i loaʻa nā pūnaewele NS7CAR-T. Ua hōʻike nā hopena ʻaʻole wale ka palekana o ka lāʻau NS7CAR-T akā ua hōʻike pū i ka hana anti-tumor kupaianaha. Ua hōʻike nā maʻi i mālama ʻia me nā pūnaewele NS7CAR-T i nā pane lapaʻau koʻikoʻi, e hōʻike ana i ka hiki o kēia lāʻau lapaʻau ma ke ʻano he mea hana ikaika e kūʻē i kēia mau maʻi kanesa paʻakikī.

ʻO nā mea noiʻi ma hope o ke aʻo ʻana e komo pū ana me kahi hui o nā loea mai ka Halemai ʻo Hebei Yanda Lu Daopei a me Hebei Senlang Biotechnology Co., Ltd. Hōʻike kā lākou mau ʻike e hiki ke hoʻoulu pono ʻia nā pūnaewele NS7CAR-T me ka ʻole o nā hoʻololi genetic hou e pale aku i ka hōʻike ʻana o CD7, e hoʻomaʻamaʻa ana i ke kaʻina hana a hoʻonui i ka pono o ka lāʻau lapaʻau.

ʻO kēia holomua i ka NS7CAR-T cell therapy e kūlike me nā hana e hoʻomau nei e hoʻomohala i nā lāʻau lapaʻau ʻoi aku ka maikaʻi no T-ALL a me T-LBL. Ke holomua nei kā mākou hui ma kēia kahua me kā mākou ponoʻī Huahana CAR-T, a mākou e manaʻoʻiʻo nei e hoʻokō i nā hopena hoʻohiki i ʻike ʻia me ka lāʻau lapaʻau NS7CAR-T.

ʻO nā hopena hoʻoikaika o kēia haʻawina e hoʻomākaukau i ke ala no ka noiʻi hou aku a me nā hoʻokolohua lapaʻau e hoʻopaʻa i ke kuleana o nā pūnaewele NS7CAR-T i ka mālama ʻana i nā maʻi ʻino T-cell i hoʻihoʻi ʻia a paʻakikī paha. I ka loaʻa ʻana o ka ʻikepili hou aku, manaʻolana ʻia e lilo koke kēia lāʻau lapaʻau i koho maʻamau no nā poʻe maʻi e hakakā nei i kēia mau maʻi ʻino.