Kafukufuku Wopambana Akuwonetsa Chitetezo ndi Kugwira Ntchito kwa Chithandizo cha CAR-T Pochiza Matenda a B-Cell

Kafukufuku waposachedwa wotsogozedwa ndi Dr. Zhi-tao Ying wochokera ku Peking University Cancer Hospital wasonyeza zotsatira zabwino pochiza khansa ya m'magazi ya B-cell yomwe yabwereranso komanso yosagwirizana ndi maselo pogwiritsa ntchito chithandizo chatsopano cha chimeric antigen receptor T (CAR-T), IM19. Yofalitsidwa mu Nyuzipepala ya Mankhwala Atsopano ku ChinaKafukufukuyu akuwonetsa kuthekera kwakukulu kwa IM19 pochiza odwala omwe agwiritsa ntchito njira zochiritsira zachikhalidwe.

Kafukufukuyu adakhudza odwala 12, omwe adagawidwa mofanana pakati pa omwe ali ndi matenda a B-cell. Lymphoma Yosakhala ya Hodgkin (NHL) ndi khansa ya m'magazi ya B-cell lymphoblastic (B-ALL). Odwalawo analandira mankhwala osiyanasiyana a maselo a IM19 CAR-T, omwe anapatsidwa pambuyo pa chithandizo cha fludarabine ndi cyclophosphamide. Mapeto akuluakulu a kafukufukuyu anali kuwunika kuchuluka kwa yankho, kupirira kwa maselo a CAR-T, kutulutsidwa kwa cytokine, ndi kuyang'anira zochitika zoyipa.

(Chithunzi chikuwonetsa kuchira kwa odwala a NHL ndi B-ALL)

Chodabwitsa n'chakuti, odwala 11 mwa odwala 12 anachira kwathunthu, ndipo magazi awo anachulukana mosavuta. Chithandizochi chinapangitsa kuti ma cytokine monga interleukin-6 ndi interleukin-10 achuluke, zomwe zikusonyeza kuti chitetezo cha mthupi chawo chinali cholimba. Chofunika kwambiri n'chakuti, palibe wodwala aliyense amene anali ndi vuto lalikulu la cytokine release syndrome kapena CAR-T cell-related encephalopathy, zomwe zinatsimikizira kuti chithandizochi chinali chabwino.

Kafukufukuyu adachitika ndi gulu logwirizana kuchokera ku Peking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, ndi Beijing Immunochina Pharmaceuticals. Dr. Ying, wolemba wamkulu, ndi katswiri pa matenda ndi kuchiza matenda a malignant lymphomas, pomwe Dr. Jun Zhu, wolemba wofanana naye, ndi katswiri wodziwika bwino pantchito yomweyi. Kafukufukuyu adathandizidwa ndi mabungwe angapo odziwika bwino, kuphatikiza National Natural Science Foundation of China ndi Beijing Natural Science Foundation.

Kafukufuku wodabwitsa uyu akupereka umboni wokwanira wakuti chithandizo cha IM19 CAR-T sichimangogwira ntchito komanso ndi chotetezeka kwa odwala omwe ali ndi khansa ya B-cell yovuta. Chimatsegula njira yofufuzira mtsogolo komanso njira zina zomwe zingagwiritsidwe ntchito kuchipatala, zomwe zimapatsa chiyembekezo kwa odwala omwe ali ndi njira zochepa zochiritsira.