Kev Tshawb Fawb Txog Kev Tshawb Fawb Qhia Txog Kev Nyab Xeeb thiab Kev Ua Haujlwm Zoo ntawm CAR-T Therapy hauv Kev Kho Mob B-Cell Malignancies
Tsis ntev los no, kev tshawb fawb uas Dr. Zhi-tao Ying los ntawm Peking University Cancer Hospital tau ua tus thawj coj tau qhia txog cov txiaj ntsig zoo hauv kev kho mob ntawm cov kab mob B-cell hematologic malignancies uas rov qab los thiab tsis kho tau siv cov tshuaj chimeric antigen receptor T (CAR-T) cell therapy tshiab, IM19. Luam tawm hauv Phau Ntawv Xov Xwm Suav Txog Cov Tshuaj Tshiab, kev tshawb fawb qhia txog lub peev xwm kho mob tseem ceeb ntawm IM19 rau cov neeg mob uas tau siv cov kev kho mob ib txwm muaj.
Txoj kev tshawb fawb no muaj 12 tus neeg mob, faib sib npaug zos ntawm cov neeg uas raug kev txom nyem los ntawm B-cell Lymphoma uas tsis yog Hodgkin (NHL) thiab mob ntshav dawb B-cell lymphoblastic leukemia (B-ALL). Cov neeg mob tau kho nrog ntau hom tshuaj IM19 CAR-T cells, uas tau txhaj tom qab kev kho mob uas muaj fludarabine thiab cyclophosphamide. Cov ntsiab lus tseem ceeb ntawm txoj kev tshawb fawb suav nrog kev ntsuam xyuas qhov nrawm ntawm kev teb tag nrho, CAR-T cell nyob ruaj khov, kev tso tawm cytokine, thiab kev saib xyuas cov xwm txheej tsis zoo.
(Daim duab qhia txog kev rov zoo ntawm cov neeg mob NHL thiab B-ALL)
Qhov tseem ceeb tshaj plaws, 11 ntawm 12 tus neeg mob tau zoo tag nrho, thiab pom tau tias muaj IM19 ntau ntxiv hauv lawv cov ntshav. Kev kho mob ua rau muaj cytokines xws li interleukin-6 thiab interleukin-10 ntau ntxiv, qhia txog kev tiv thaiv kab mob zoo. Qhov tseem ceeb, tsis muaj ib tus neeg mob twg tau muaj mob cytokine release syndrome hnyav lossis CAR-T cell-related encephalopathy, uas qhia txog kev nyab xeeb ntawm kev kho mob.
Cov kev tshawb fawb no tau ua los ntawm pab pawg neeg koom tes los ntawm Peking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, thiab Beijing Immunochina Pharmaceuticals. Dr. Ying, tus sau ua tus thawj coj, tshwj xeeb hauv kev kuaj mob thiab kho cov kab mob lymphomas malignant, thaum Dr. Jun Zhu, tus sau ntawv sib xws, yog ib tus kws tshaj lij nto moo hauv tib qho chaw. Kev tshawb fawb no tau txais kev txhawb nqa los ntawm ntau qhov nyiaj pab tseem ceeb, suav nrog National Natural Science Foundation of China thiab Beijing Natural Science Foundation.
Txoj kev tshawb fawb tshiab no muab pov thawj ntau heev tias kev kho mob IM19 CAR-T tsis yog tsuas yog ua tau zoo xwb tab sis kuj muaj kev nyab xeeb rau cov neeg mob uas muaj mob qog nqaij hlav B-cell. Nws yog txoj hauv kev rau kev tshawb fawb yav tom ntej thiab kev siv tshuaj kho mob, muab kev cia siab tshiab rau cov neeg mob uas muaj kev xaiv kho mob tsawg.