Uphononongo oluPhambili lubonisa uKhuseleko kunye nokusebenza kakuhle koNyango lwe-CAR-T ekunyangeni iintsholongwane ze-B-Cell
Uphononongo lwakutshanje olukhokelwa nguGqr. Zhi-tao Ying wasePeking University Cancer Hospital lubonise iziphumo ezithembisayo kunyango lwe-B-cell malignancies ephinde yabuya kwaye ingenamsebenzi kusetyenziswa unyango olutsha lwe-chimeric antigen receptor T (CAR-T) cell, IM19. Ipapashwe kwi Ijenali yaseTshayina yeZiyobisi eziNtsha, olu phando lubonisa amandla abalulekileyo okunyanga e-IM19 kwizigulana eziye zasebenzisa iindlela zonyango eziqhelekileyo.
Olu phononongo lubandakanye izigulane ezili-12, ezahlulwe ngokulinganayo phakathi kwezo zinesifo se-B-cell I-Non-Hodgkin Lymphoma (NHL) kunye ne-acute B-cell lymphoblastic leukemia (B-ALL). Izigulana zinyangwe ngeedosi ezahlukeneyo zeeseli ze-IM19 CAR-T, ezathi zafakwa emva konyango olubandakanya i-fludarabine kunye ne-cyclophosphamide. Isiphelo esiphambili sophando sasiquka ukuvavanya izinga lokuphendula lilonke, ukuqhubeka kweeseli ze-CAR-T, ukukhululwa kwe-cytokine, kunye nokubeka esweni iziganeko ezimbi.
(Umfanekiso ubonisa indlela abachacha ngayo abaguli be-NHL kunye ne-B-ALL)
Okumangalisayo kukuba, izigulane ezili-11 kwezili-12 zifumene ukuphumla okupheleleyo, kunye nokwanda kwe-IM19 egazini lazo. Olu nyango lubangele ukwanda kwee-cytokines ezifana ne-interleukin-6 kunye ne-interleukin-10, nto leyo ebonisa impendulo enamandla yomzimba. Okubalulekileyo kukuba, akukho namnye kwizigulane oye waba ne-cytokine release syndrome enzima okanye i-CAR-T cell-related encephalopathy, nto leyo egxininisa ukhuseleko olufanelekileyo lonyango.
Olu phando lwenziwe liqela elisebenzisanayo elivela kwiPeking University Cancer Hospital, kwiHebei Yanda Lu Daopei Hospital, nakwiBeijing Immunochina Pharmaceuticals. UGqr. Ying, umbhali ophambili, ugxile ekuxilongeni nasekunyangeni ii-lymphomas ezinobungozi, ngelixa uGqr. Jun Zhu, umbhali ohambelanayo, eyingcali eyaziwayo kwicandelo elifanayo. Olu phando luxhaswe zizibonelelo ezininzi ezidumileyo, kuquka iNational Natural Science Foundation yaseTshayina kunye neBeijing Natural Science Foundation.
Olu phononongo lubalaseleyo lubonelela ngobungqina obucacileyo bokuba unyango lwe-IM19 CAR-T alusebenzi nje kuphela kodwa lukhuselekile nakwizigulane ezineengxaki ze-B-cell. Luvula indlela yophando lwexesha elizayo kunye nokusetyenziswa kwezonyango okunokwenzeka, lunika ithemba elitsha kwizigulane ezineendlela zonyango ezinqongopheleyo.