Ubushakashatsi bw'Iterambere bwerekanye Umutekano n'Ingufu z'Ubuvuzi bwa CAR-T mu Kuvura Malignancies za B-Seli
Ubushakashatsi buherutse gukorwa buyobowe na Dr. Zhi-tao Ying wo mu bitaro bya Peking University Cancer Hospital bwagaragaje umusaruro mwiza mu kuvura kanseri y’amaraso ya B-cell hematologic yasubiwemo kandi idashobora kugaragara hakoreshejwe uburyo bushya bwo kuvura bwa chimeric antigen receptor T (CAR-T), IM19. Byasohotse mu kinyamakuru IM19. Ikinyamakuru cy'Abashinwa cy'Imiti Mishya, ubushakashatsi bwerekana ubushobozi bukomeye bwa IM19 mu kuvura abarwayi barangije uburyo busanzwe bwo kuvura.
Ubushakashatsi bwakorewe ku barwayi 12, bagabanyijemo ibice bingana hagati y’abarwaye uturemangingo twa B Lymphoma itari iya Hodgkin (NHL) na kanseri y’amaraso ya B-cell lymphoblastic (B-ALL) ikabije. Abarwayi bavuwe hakoreshejwe ingero zitandukanye z’uturemangingo twa CAR-T twa IM19, twashyizwemo nyuma yo guhabwa fludarabine na cyclophosphamide. Ingaruka z’ibanze z’ubushakashatsi zari zikubiyemo gusuzuma igipimo rusange cy’ubutabazi, gukomeza kwangirika kw’uturemangingo twa CAR-T, kurekurwa kwa cytokine, no gukurikirana ingaruka mbi.
(Ishusho igaragaza gukira kw'abarwayi ba NHL na B-ALL)
Igitangaje ni uko abarwayi 11 muri 12 bakize burundu, amaraso yabo agaragara neza, IM19 ikwirakwira. Ubu buvuzi bwatumye habaho kwiyongera kwa cytokines nka interleukin-6 na interleukin-10, bigaragaza ko ubudahangarwa bw'umubiri buhagaze neza. Icy'ingenzi ni uko nta murwayi n'umwe wigeze agira ikibazo gikomeye cyo kurekura cytokine cyangwa indwara ya CAR-T cell-related encephalopathy, ibi bikaba bigaragaza umutekano mwiza w'ubu buvuzi.
Ubushakashatsi bwakozwe n'itsinda rifatanyije ry'ibitaro bya Peking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, na Beijing Immunochina Pharmaceuticals. Dr. Ying, umwanditsi mukuru, ni umuhanga mu gusuzuma no kuvura kanseri y'ibicurane, mu gihe Dr. Jun Zhu, umwanditsi ujyanye na byo, ari impuguke izwi muri urwo rwego. Ubu bushakashatsi bwashyigikiwe n'inkunga nyinshi zizwi, harimo n'Ikigo cy'Igihugu cy'Ubumenyi bw'Inyamaswa cy'Ubushinwa n'Ikigo cy'Ubumenyi bw'Inyamaswa cya Beijing.
Ubu bushakashatsi bw’ibanze butanga ibimenyetso bifatika byerekana ko uburyo bwo kuvura bwa IM19 CAR-T budafite ingaruka gusa ku barwayi bafite kanseri y’uturemangingo twa B bugoye. Butanga inzira y’ubushakashatsi bw’ejo hazaza n’uburyo bushobora gukoreshwa mu buvuzi, butanga icyizere gishya ku barwayi bafite uburyo buke bwo kuvura.