Chidzidzo Chebudiriro Chinoratidza Kuchengetedzeka uye Kushanda Kwekurapa kweCAR-T Mukurapa Maronda eB-Cell
Ongororo ichangobva kuitwa yakatungamirwa naDr. Zhi-tao Ying wekuPeking University Cancer Hospital yakaratidza mhedzisiro yakanaka mukurapa kwezvirwere zveropa zveB-cell zvinodzoka uye zvisingachashandiswi uchishandisa mushonga mutsva we chimeric antigen receptor T (CAR-T) cell therapy, IM19. Yakaburitswa mu Chinyorwa cheChinese cheMishonga Mitsva, tsvakurudzo iyi inoratidza kugona kukuru kwekurapa kweIM19 muvarwere vakashandisa nzira dzekurapa dzechinyakare.
Chidzidzo ichi chaisanganisira varwere gumi nevaviri, vakakamurwa zvakaenzana pakati peavo vane chirwere cheB-cell. Lymphoma isiri yeHodgkin (NHL) uye acute B-cell lymphoblastic leukemia (B-ALL). Varwere vakarapwa nemasero eIM19 CAR-T akasiyana-siyana, ayo akaiswa mushure mekurapwa kwaisanganisira fludarabine necyclophosphamide. Mhedzisiro huru yechidzidzo ichi yaisanganisira kuongorora huwandu hwemhinduro, kuramba kwemasero eCAR-T, kuburitswa kwecytokine, uye kutarisa zviitiko zvakaipa.
(Mufananidzo unoratidza kupora kwevarwere veNHL neB-ALL)
Zvinoshamisa kuti, 11 pavarwere gumi nevaviri vakawana zororo rakazara, nekuwedzera kweIM19 muropa ravo. Kurapa uku kwakakonzera kuwedzera kwema cytokines akadai se interleukin-6 ne interleukin-10, zvichiratidza kuti immune response yakasimba. Zvakakosha kuti hapana kana mumwe wevarwere ava akawana cytokine release syndrome kana CAR-T cell-related encephalopathy, zvichiratidza kuti kurapwa uku kwakachengeteka.
Ongororo iyi yakaitwa nechikwata chakabatana kubva kuPeking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, neBeijing Immunochina Pharmaceuticals. Dr. Ying, munyori mukuru, anonyanya kuongorora nekurapa malignant lymphomas, ukuwo Dr. Jun Zhu, munyori anoenderana naye, inyanzvi ine mukurumbira munyaya imwe chete iyi. Ongororo iyi yakatsigirwa nemari yakawanda inopihwa, kusanganisira National Natural Science Foundation of China neBeijing Natural Science Foundation.
Chidzidzo ichi chinoshamisa chinopa humbowo hwakasimba hwekuti kurapwa neIM19 CAR-T hakungoshandi chete asiwo kwakachengeteka kune varwere vane kenza yeB-cell inonetsa. Kunovhura nzira yekutsvagisa mune ramangwana uye kushandiswa kwekiriniki, zvichipa tariro itsva kuvarwere vane nzira shoma dzekurapa.