Ua hōʻike ka Haʻawina Hou i ka Palekana a me ka Pono o ka CAR-T Therapy i ka mālama ʻana i nā maʻi ʻino B-Cell
Ua hōʻike ʻia kahi noiʻi hou i alakaʻi ʻia e Kauka Zhi-tao Ying mai ka Halemai Kanesa o ke Kulanui ʻo Peking i nā hopena hoʻohiki i ka mālama ʻana i nā maʻi hematologic B-cell relapsed a me refractory me ka hoʻohana ʻana i kahi chimeric antigen receptor T (CAR-T) cell therapy hou, IM19. Paʻi ʻia ma ka Ka Nūpepa Kina no nā Lāʻau Lapaʻau Hou, hōʻike ka noiʻi i ka hiki ke hoʻōla nui o IM19 i nā poʻe maʻi i pau nā koho lapaʻau maʻamau.
Ua pili ka haʻawina i 12 mau maʻi, i māhele like ʻia ma waena o ka poʻe e ʻeha nei me ka B-cell ʻO ka Lymphoma Non-Hodgkin (NHL) a me ka leukemia lymphoblastic B-cell acute (B-ALL). Ua mālama ʻia nā maʻi me nā ʻano like ʻole o nā pūnaewele IM19 CAR-T, i hoʻokomo ʻia ma hope o kahi regimen conditioning e pili ana i ka fludarabine a me ka cyclophosphamide. ʻO nā hopena mua o ke aʻo ʻana, ʻo ia ka loiloi ʻana i ka helu pane holoʻokoʻa, ka hoʻomau ʻana o nā pūnaewele CAR-T, ka hoʻokuʻu ʻana o ka cytokine, a me ka nānā ʻana i nā hanana maikaʻi ʻole.
（Hōʻike ke kiʻi i ka hoʻōla ʻana o nā maʻi NHL a me B-ALL）
ʻO ka mea kupaianaha, ua loaʻa i ka 11 o nā maʻi 12 ke kala piha ʻana, me ka hoʻonui ʻia ʻana o IM19 i loko o ko lākou koko. Ua hoʻoulu ka lāʻau lapaʻau i ka hoʻonui ʻia o nā cytokines e like me ka interleukin-6 a me ka interleukin-10, e hōʻike ana i kahi pane pale ikaika. ʻO ka mea nui, ʻaʻohe o nā maʻi i loaʻa i ka cytokine release syndrome koʻikoʻi a i ʻole ka encephalopathy pili i nā cell CAR-T, e hōʻike ana i ka palekana maikaʻi o ka lāʻau lapaʻau.
Ua mālama ʻia ka noiʻi e kahi hui hana like mai ka Halemai Kanesa o ke Kulanui ʻo Peking, ka Halemai ʻo Hebei Yanda Lu Daopei, a me Beijing Immunochina Pharmaceuticals. ʻO Kauka Ying, ke alakaʻi kākau, he loea i ka ʻike a me ka mālama ʻana i nā lymphomas malignant, ʻoiai ʻo Kauka Jun Zhu, ka mea kākau pili, he loea kaulana ia ma ke kahua like. Ua kākoʻo ʻia kēia noiʻi e kekahi mau makana hanohano, me ka National Natural Science Foundation of China a me ka Beijing Natural Science Foundation.
Hāʻawi kēia haʻawina hou i nā hōʻike koʻikoʻi e hōʻike ana ʻaʻole wale ka maikaʻi o ka lāʻau lapaʻau IM19 CAR-T akā palekana nō hoʻi no nā poʻe maʻi me nā maʻi ʻino B-cell paʻakikī. Hoʻomākaukau ia i ke ala no ka noiʻi e hiki mai ana a me nā noi lapaʻau kūpono, e hāʻawi ana i ka manaʻolana hou i nā poʻe maʻi me nā koho lapaʻau palena ʻole.