Ucwaningo Oluphumelelayo Lubonisa Ukuphepha Nokusebenza Kahle Kokwelashwa Kwe-CAR-T Ekwelapheni Ukulimala Kwamaseli E-B
Ucwaningo lwamuva oluholwa nguDkt. Zhi-tao Ying wasePeking University Cancer Hospital lubonise imiphumela ethembisayo ekwelapheni umdlavuza we-B-cell ophinde wabuyela esimweni sawo futhi ongaphili kahle kusetshenziswa ukwelashwa okusha kweseli le-chimeric antigen receptor T (CAR-T), i-IM19. Kushicilelwe ku- Ijenali YaseShayina Yezidakamizwa Ezintsha, ucwaningo luqokomisa amandla abalulekile okwelapha e-IM19 ezigulini esezisebenzise izindlela zokwelapha ezivamile.
Ucwaningo luhilele iziguli ezingu-12, ezihlukaniswe ngokulinganayo phakathi kwalezo ezihlushwa yi-B-cell I-Non-Hodgkin Lymphoma (NHL) kanye ne-acute B-cell lymphoblastic leukemia (B-ALL). Iziguli zelashwe ngemithamo ehlukahlukene yamaseli e-IM19 CAR-T, afakwa ngemuva kokwelashwa okubandakanya i-fludarabine kanye ne-cyclophosphamide. Iziphetho eziyinhloko zocwaningo zazihlanganisa ukuhlola izinga lokuphendula lilonke, ukuphikelela kwamaseli e-CAR-T, ukukhishwa kwe-cytokine, kanye nokuqapha izehlakalo ezimbi.
(Isithombe sibonisa ukululama kweziguli ze-NHL neze-B-ALL)
Okuphawulekayo ukuthi iziguli ezingu-11 kwezingu-12 zithole ukuphulukiswa okuphelele, kanye nokwanda kwe-IM19 egazini lazo. Ukwelashwa kwabangela ukwanda kwama-cytokine njenge-interleukin-6 kanye ne-interleukin-10, okubonisa impendulo eqinile yomzimba. Okubalulekile ukuthi akekho noyedwa weziguli owake waba ne-cytokine release syndrome noma i-CAR-T cell-related encephalopathy, okugcizelela iphrofayili yokuphepha enhle yokwelashwa.
Ucwaningo lwenziwe yithimba elibambisene nePeking University Cancer Hospital, Hebei Yanda Lu Daopei Hospital, kanye neBeijing Immunochina Pharmaceuticals. UDkt. Ying, umbhali oholayo, ugxile ekuxilongweni nasekulapheni ama-lymphomas abulalayo, kanti uDkt. Jun Zhu, umbhali ohambisanayo, unguchwepheshe odumile emkhakheni ofanayo. Lolu cwaningo lusekelwe yizibonelelo eziningana ezihlonishwayo, okuhlanganisa iNational Natural Science Foundation of China kanye neBeijing Natural Science Foundation.
Lolu cwaningo oluqavile lunikeza ubufakazi obuningi bokuthi ukwelashwa kwe-IM19 CAR-T akugcini nje ngokusebenza kahle kodwa futhi kuphephile ezigulini ezinezinkinga zomdlavuza we-B-cell eziyinselele. Luvula indlela yocwaningo lwesikhathi esizayo kanye nezicelo zomtholampilo ezingaba khona, lunikeza ithemba elisha ezigulini ezinezinketho zokwelapha ezilinganiselwe.