E whakaatu ana te Rangahau Hou i te Haumaru me te Whai Huatanga o te Whakaora CAR-T i roto i te Rongoā i ngā Mate Pukupuku Pūtau-B
Kua whakaatuhia e tētahi rangahau hou nā Tākuta Zhi-tao Ying o te Peking University Cancer Hospital ngā hua whai hua mō te rongoā i ngā mate pukupuku toto pūtau-B kua hoki mai me te uaua ki te whakamahi i tētahi rongoā pūtau T chimeric antigen receptor (CAR-T) hou, IM19. I whakaputaina ki te Te Puka Hainamana mō ngā Tarukino Hou, e whakaatu ana te rangahau i te kaha whakaora nui o te IM19 i roto i ngā tūroro kua pau katoa ngā huarahi maimoatanga tuku iho.
Tekau mā rua ngā tūroro i uru ki te rangahau, ā, i wehea ōritetia te hunga e pāngia ana e te mate pūtau-B. Lymphoma Kore-Hodgkin (NHL) me te mate pukupuku toto pūtau-B whakapeka (B-ALL). I rongoatia ngā tūroro ki ngā horopeta rerekē o ngā pūtau IM19 CAR-T, i tukuna i muri i te tikanga whakatikatika e uru ana ki te fludarabine me te cyclophosphamide. Ko ngā pito whakamutunga matua o te rangahau ko te aromatawai i te tere urupare whānui, te pumau o ngā pūtau CAR-T, te tukunga cytokine, me te aroturuki i ngā pānga kino.
（E whakaatu ana te pikitia i te whakaoranga o ngā tūroro NHL me B-ALL）
He mea whakamiharo, 11 o ngā tūroro 12 i whiwhi i te whakaoranga katoa, me te kitea o te horapa o te IM19 i roto i ō rātou toto. Nā te rongoā i piki ake ai ngā cytokine pēnei i te interleukin-6 me te interleukin-10, e tohu ana i te kaha o te urupare ārai mate. He mea nui, kāore tetahi o ngā tūroro i pāngia e te mate tukunga cytokine kino, te encephalopathy e pā ana ki ngā pūtau CAR-T rānei, e whakaatu ana i te pai o te haumaru o te rongoā.
I whakahaerehia te rangahau e tētahi rōpū mahi tahi mai i te Peking University Cancer Hospital, te Hebei Yanda Lu Daopei Hospital, me te Beijing Immunochina Pharmaceuticals. Ko Tākuta Ying, te kaituhi matua, he tohunga ki te tātaritanga me te rongoā i ngā lymphoma kino, ko Tākuta Jun Zhu, te kaituhi e pā ana, he tohunga rongonui i taua mara. I tautokona tēnei rangahau e ētahi putea whaimana, tae atu ki te National Natural Science Foundation o Haina me te Beijing Natural Science Foundation.
He taunakitanga nui tēnei rangahau hou e whakaatu ana ehara i te mea he whai hua anake te rongoā IM19 CAR-T engari he haumaru hoki mō ngā tūroro e pangia ana e ngā mate pukupuku pūtau-B uaua. Ka whakatakoto huarahi mō ngā rangahau ā muri ake nei me ngā tono haumanu pea, ka tukuna he tumanako hou ki ngā tūroro he iti noa ngā kōwhiringa maimoatanga.