Iindaba
Unyango lwe-CAR-T oluPhambili kwi-B-cell Acute Lymphoblastic Leukemia lubonisa ukusebenza okungazange kubonwe ngaphambili
Uphononongo oluphambili lubonisa ukusebenza okumangalisayo konyango lweeseli ze-CAR-T ekunyangeni i-B-cell Acute Lymphoblastic Leukemia (B-ALL). Olu phando, olubandakanya intsebenziswano ne-BIOOCUS kunye neSibhedlele saseLu Daopei, lubonisa inkqubela phambili ebalulekileyo, lumisela unyango njengokhetho olubalulekileyo lonyango.
Unyango lweeCell zeCAR-T ezintsha luguqula unyango lweeB Cell Malignancies
Abaphandi abavela kwiSibhedlele iLu Daopei kunye nabasebenzi bamanye amazwe bahlola unyango lweeseli zeCAR-T oluphambili, olunika ithemba kwizigulana ezine-B cell monicancies. Olu phononongo lubonisa inkqubela phambili kuyilo kunye nokusetyenziswa, lubonisa iziphumo ezithembisayo kunye namathuba okuvelisa izinto ezintsha kwixesha elizayo.
Ukusebenza Okuphuculweyo Kwe-Antitumor yeeSeli ze-CD19 CAR-T ezisekwe kwi-4-1BB ekunyangeni i-B-ALL
Izifundo zeklinikhi zakutshanje zityhila ukuba iiseli ze-CD19 CAR-T ezisekelwe kwi-4-1BB zibonisa ukusebenza kakuhle kakhulu ekulweni nethumba xa kuthelekiswa neeseli ze-CAR-T ezisekelwe kwi-CD28 ekunyangeni i-B cell ephinde yabuyela kwi-relaxation okanye enganyangekiyo (r/r B-ALL).
Unyango lwe-CD19 CAR-T oluphantsi lweSibhedlele iLu Daopei lubonisa iziphumo ezithembisayo kwizigulana ze-B-ALL
Uphononongo lwakutshanje kwiSibhedlele iLu Daopei lubonise ukusebenza kakuhle kunye nokhuseleko oluphezulu lwe-CD19 CAR-T cell therapy yedosi ephantsi ekunyangeni izigulane ze-B acute lymphoblastic leukemia (B-ALL) eziphinde zagula okanye eziphinde zagula. Olu phando, oluquka izigulane ezingama-51, lubonise izinga elimangalisayo lokuxolelwa ngokupheleleyo kunye neziphumo ebezingalindelekanga ezincinci.
Icebo Lokukhuthaza Elitsha Liphucula Ukhuseleko kunye Nokusebenza Kakuhle Konyango lwe-CAR-T kwi-Acute B Cell Leukemia
Isibhedlele iLu Daopei kunye neHebei Senlang Biotechnology zibhengeze iziphumo ezithembisayo ezivela kuphando lwazo lwakutshanje malunga nokhuseleko kunye nokusebenza kakuhle konyango lwe-CAR-T kwi-acute B cell leukemia. Le ntsebenziswano igxininisa amandla oyilo olutsha lweeseli ze-CAR-T ukuphucula iziphumo zesigulana.
Uphononongo oluPhambili lubonisa uKhuseleko kunye nokusebenza kakuhle koNyango lwe-CAR-T ekunyangeni iintsholongwane ze-B-Cell
Uphononongo olutsha olukhokelwa nguGqr. Zhi-tao Ying wasePeking University Cancer Hospital lubonise ukhuseleko kunye nokusebenza kakuhle konyango lweeseli ze-IM19 CAR-T ekunyangeni umhlaza we-B-cell obuyela umva kunye nongasasebenziyo. Ipapashwe kwi Ijenali yaseTshayina yeZiyobisi eziNtsha, olu phononongo luxela ukuba izigulane ezili-11 kwezili-12 zifumene ukuphumla ngokupheleleyo ngaphandle kwemiphumo emibi kakhulu, nto leyo ebonisa amandla e-IM19 njengonyango oluthembisayo kwizigulane ezinezinye iindlela ezinqongopheleyo.
Inkqubela phambili kwiNatural Killer (NK) Cells Kwiminyaka engaphezu kwama-50
Kwiminyaka engamashumi amahlanu edlulileyo, uphando ngeeseli zeNatural Killer (NK) luye lwaguqula indlela esiqonda ngayo ukuzikhusela komzimba, nto leyo esinika iindlela ezintsha ezithembisayo zonyango lomhlaza kunye nentsholongwane.
Uqeqesho Lonyaka Lolawulo Lwegazi Lwezonyango Nobuchwephesha Bokutofelwa Kwegazi Olubanjelwe kwiSibhedlele iYanda Ludaopei
UQeqesho lwaminyaka le luka-2024 loLawulo lweGazi lweKliniki kunye neTekhnoloji yoTyalelo lwegazi eSanhe City lubanjwe ngempumelelo kwiSibhedlele iYanda Ludaopei. Lo msitho ujolise ekuphuculeni ulawulo lwegazi lweklinikhi kunye nokhuseleko lotofelo-gazi ngeeseshoni zoqeqesho ezibanzi ezizinyaswe ziingcali zempilo ezingaphezu kwe-100 ezivela kumaziko ezonyango ahlukeneyo.
Uphuhliso kwiSifo se-Autoimmune sabantwana: Unyango lweeSeli ze-CAR-T luphilisa iSigulana seLupus
Uphononongo oluphambili kwiSibhedlele saseYunivesithi yase-Erlangen lwanyanga ngempumelelo intombazana eneminyaka eli-16 ubudala ene-systemic lupus erythematosus (SLE) enzima kusetyenziswa unyango lweeseli ze-CAR-T. Oku kuphawula ukusetyenziswa kokuqala kolu nyango lwe-lupus yabantwana, okunika ithemba elitsha kubantwana abanezifo zokuzikhusela komzimba.
Ukuphucula ukusebenza kakuhle kwePROTAC: Uphononongo oluQhubayo
Uphononongo lwakutshanje kwi-Nature Communications lutyhila ulwazi oluphambili malunga neendlela zokubonisa ezingaphakathi ezilawula ukusebenza kakuhle kokuwohloka kweeproteni ezijoliswe kuzo kusetyenziswa ii-PROTACs. Olu fumaniso lunokuvula indlela yonyango olusebenzayo ngakumbi lomhlaza nezinye izifo.
Ukukhuthaza Impilo Nokuchacha: Ukhathalelo Lwemihla Ngemihla Lwezigulane EzineLeukemia
Ukuqinisekisa amava onyango olukhuselekileyo nolukhululekileyo kwizigulane ezine-leukemia kubandakanya ukhathalelo olucokisekileyo lwemihla ngemihla, kubandakanya ucoceko lokusingqongileyo, ucoceko lomntu, ukutya okunempilo, kunye nokuzilolonga okufanelekileyo. Esi sikhokelo sinika iingcebiso ezibalulekileyo zokhathalelo olusebenzayo lwemihla ngemihla ukuxhasa ukuchacha.
Unyango lweeSeli zeNS7CAR-T lubonisa isithembiso sokunyanga i-R/R T-ALL/LBL
Uphononongo lwakutshanje lubonisa ukusebenza kakuhle kunye nokhuseleko lwe-NS7CAR-T cell therapy ekunyangeni i-T-cell acute lymphoblastic leukemia (R/R T-ALL) ephinde yabuyela kwi-relaxation okanye i-refractory okanye i-refractory T-cell lymphoblastic lymphoma (R/R T-LBL). Olu nyango lunika ithemba elitsha kwizigulane ezinezi ntlobo zomhlaza eziqatha.