Unyango lwe-CAR-T oluPhambili kwi-B-cell Acute Lymphoblastic Leukemia lubonisa ukusebenza okungazange kubonwe ngaphambili
Uphononongo lwakutshanje luzise iindaba ezithembisayo kwizigulana ezine-B-cell Acute Lymphoblastic Leukemia (B-ALL), lubonisa ukusebenza kakuhle kunye nokhuseleko olumangalisayo lonyango lwe-chimeric antigen receptor-T cell (CAR-T). Olu phando, olwenziwe ngentsebenziswano ne-BIOOCUS kunye neSibhedlele iLu Daopei, lugxininisa amandla onyango lwe-CAR-T okuguqula unyango lolu hlobo lwe-leukemia olunobundlongondlongo.
Olu phononongo luhlolisise ngononophelo iziphumo zonyango zezigulane ezinyangwe ngeeseli ze-CAR-T, zigxile ekukwazini kwazo ukujolisa nokususa iiseli ze-B ezinomhlaza. Iziphumo beziyinto entsha kakhulu, apho inani elikhulu lezigulane lifumene ukuphumla ngokupheleleyo. Le mpumelelo ayibonisi nje kuphela amandla onyango lwe-CAR-T kodwa ikwayibeka njengonyango oluphambili lwe-B-ALL.
I-BIOOCUS, ngokubambisana neSibhedlele esidumileyo saseLu Daopei, ibisoloko iphambili kolu phando lutsha. Intsebenziswano phakathi kwala maqela mabini ibe negalelo elikhulu ekuphuculeni unyango lwe-CAR-T, ukuqinisekisa ukuba izigulane zifumana unyango oluphambili oluxhaswa luphando olunzulu lwesayensi. Olu phononongo lugxininisa ngakumbi ukubaluleka kobudlelwane obucwangcisiweyo ekuphuhlisweni konyango olusindisa ubomi.
Uluntu lwezonyango lwamazwe ngamazwe luziqaphele ezi ziphumo, luqonda impembelelo yotshintsho yonyango lwe-CAR-T kwi-oncology. Njengoko izigulane ze-B-ALL kwihlabathi liphela zifuna iindlela zonyango ezisebenzayo, olu phononongo lunika ithemba elitsha, luqinisa indima yonyango lwe-CAR-T kwikamva le Unyango lomhlaza.
Kwizigulane kunye neentsapho ezilwa ne-B-ALL, olu phando lubonelela ngethemba. Ngokuqhubeka nokuqhubela phambili kunye nenkxaso yemibutho efana ne-BIOOCUS kunye neSibhedlele iLu Daopei, ikamva lonyango lwe-CAR-T libonakala liqaqambile kunangaphambili.
Ukuba wena okanye umntu omthandayo nichaphazeleka yi-B-cell Acute Lymphoblastic Leukemia kwaye ninomdla wokuhlola unyango lwe-CAR-T, siyanimema ukuba ninxibelelane nathi ukuze nifumane ulwazi oluthe kratya. Iqela lethu elizinikeleyo lilapha ukunixhasa kuyo yonke inyathelo lohambo lwenu lonyango.