Ukusebenza Okuphuculweyo Kwe-Antitumor yeeSeli ze-CD19 CAR-T ezisekwe kwi-4-1BB ekunyangeni i-B-ALL

Kwisifundo esibalulekileyo seklinikhi esenziwe yiLu Daopei Hospital kunye neLu Daopei Institute of Hematology, abaphandi bafumanise ukuba iiseli ze-CD19 CAR-T ezisekelwe kwi-4-1BB zibonelela ngenye indlela ethembisayo kwiiseli ze-CAR-T zemveli ezisekelwe kwi-CD28 zokunyanga i-B cell ephinde yabuya okanye enganyangekiyo i-acute lymphoblastic leukemia (r/r B-ALL). Olu phononongo, olubandakanya uphando oluqatha lweklinikhi lwangaphambi kweklinikhi noluphononongayo, lubonise ukuba iiseli ze-4-1BB CAR-T aziboneleli nje kuphela ngokusebenza okuphezulu kokulwa nethumba kodwa zikwabonisa ukunyamezela ixesha elide kwizigulana xa kuthelekiswa neeseli ze-CD28.

Iqela lophando leSibhedlele iLu Daopei lithelekise ngononophelo ukusebenza kwezi ntlobo zimbini zeeseli ze-CAR-T. Bafumanise ukuba, phantsi kwenkqubo efanayo yokuvelisa, iiseli ze-4-1BB CAR-T zinefuthe elinamandla lokulwa nethumba kwiidosi eziphantsi kwaye zibangele iziganeko ezimbi ezimbalwa kuneeseli ze-CD28 CAR-T. Iziphumo zophando zibonisa ukuba unyango lwe-4-1BB-based CAR-T lunokubonelela ngonyango olusebenzayo nolukhuselekileyo ngakumbi kwizigulana ezinesifo se-r/r B-ALL.

Ezi ziphumo zigxininisa ukuzinikela kweSibhedlele iLu Daopei ekuphuculeni i-hematology kunye Unyango lwe-immunotherapy, inika ithemba kwizigulana ezingakhange zisabele kunyango oluqhelekileyo. Olu phononongo, olulandele imigangatho yokuziphatha engqongqo kwaye lwamkelwe yiKomiti yoBuchule beSibhedlele iLu Daopei, lugxininisa indima yesibhedlele ekukhokeleni uphando olutsha kunyango lweeseli zeCAR-T.

Ngenxa yale mpumelelo, iLu Daopei Institute of Hematology iyaqhubeka nokuba nguvulindlela kwimida emitsha kuphando lwezonyango, ibonelela ngeendlela zonyango ezisemgangathweni ophezulu kunye nokuphucula iziphumo zesigulana. Olu phuculo lububungqina bokuzinikela kunye nobuchule bamaqela ezonyango kunye nophando eSibhedlele iLu Daopei.