Kubudirira Kwakawedzerwa Kwekudzivirira Tumor kwe4-1BB-Based CD19 CAR-T Cells mukurapa B-ALL

Muchidzidzo chakakosha chekiriniki chakaitwa neLu Daopei Hospital neLu Daopei Institute of Hematology, vaongorori vakaona kuti masero eCD19 CAR-T ane 4-1BB anopa imwe nzira inovimbisa pane masero ekare eCD28-based CAR-T ekurapa B cell inodzokera shure kana kuti isingadzoreki acute lymphoblastic leukemia (r/r B-ALL). Chidzidzo ichi, chaisanganisira kuferefeta kwakasimba kwekiriniki isati yatanga uye yekuongorora, chakaratidza kuti masero e4-1BB CAR-T haangope chete simba rekudzivirira bundu asiwo anoratidza kugara kwenguva refu muvarwere zvichienzaniswa nemasero eCD28.

Chikwata chekutsvagisa cheLu Daopei Hospital chakaenzanisa zvakanyatsonaka mashandiro emhando mbiri idzi dzemasero eCAR-T. Vakaona kuti, pasi pemaitiro akafanana ekugadzira, masero e4-1BB CAR-T aive nesimba guru rekudzivirira bundu pamishonga yakaderera uye akakonzera zviitiko zvishoma zvakaipa zvakanyanya kupfuura masero eCD28 CAR-T. Mhedzisiro yechidzidzo ichi inoratidza kuti kurapwa kwe4-1BB-based CAR-T kunogona kupa sarudzo yekurapa inoshanda uye yakachengeteka kune varwere vanotambura neR/R B-ALL.

Zvakawanikwa izvi zvinosimbisa kuzvipira kweLu Daopei Hospital mukusimudzira kurapa kweropa nezvirwere zveropa. Kurapa nekudzivirira muviri, ichipa tariro kuvarwere vasina kupindura kurapwa kwakajairika. Chidzidzo ichi, chakatevedzera mitemo yakasimba yetsika uye chakatenderwa neLu Daopei Hospital Ethics Committee, chinosimbisa basa rechipatara mukutungamira tsvakurudzo itsva mukurapa kweCAR-T cell.

Nekubudirira uku, Lu Daopei Institute of Hematology inoramba ichipa nzira itsva dzekutsvaga mishonga, ichipa nzira dzekurapa dzepamusoro-soro uye ichivandudza mhedzisiro yevarwere. Kufambira mberi uku kunoratidza kuzvipira uye hunyanzvi hwezvikwata zvekurapa nekutsvaga zveLu Daopei Hospital.