Ingantaccen Ingancin Maganin Ciwon Ƙari na Kwayoyin CAR-T na CD19 4-1BB don Magance B-ALL

A wani gagarumin bincike na asibiti da Asibitin Lu Daopei da Cibiyar Nazarin Hematology ta Lu Daopei suka gudanar, masu bincike sun gano cewa ƙwayoyin CAR-T na CD19 masu tushen 4-1BB suna ba da madadin gargajiya na CAR-T masu tushen CD28 don magance cutar sankarar lymphoblastic mai saurin kamuwa da cutar B cell (r/r B-ALL). Wannan binciken, wanda ya ƙunshi bincike mai zurfi kafin a fara aiki da kuma bincike na asibiti, ya nuna cewa ƙwayoyin CAR-T na 4-1BB ba wai kawai suna ba da ingantaccen maganin ƙari ba, har ma suna nuna juriya mai tsawo ga marasa lafiya idan aka kwatanta da takwarorinsu na CD28.

Ƙungiyar bincike ta Asibitin Lu Daopei ta kwatanta aikin waɗannan nau'ikan ƙwayoyin CAR-T guda biyu da kyau. Sun gano cewa, a ƙarƙashin tsarin kera su ɗaya, ƙwayoyin CAR-T 4-1BB suna da tasirin hana ƙari mai ƙarfi a ƙananan allurai kuma suna haifar da ƙarancin mummunan sakamako fiye da ƙwayoyin CAR-T na CD28. Sakamakon binciken ya nuna cewa maganin CAR-T na 4-1BB na iya bayar da zaɓi mafi inganci da aminci ga marasa lafiya da ke fama da r/r B-ALL.

Waɗannan binciken sun nuna jajircewar Asibitin Lu Daopei wajen haɓaka ilimin jini da kuma Maganin rigakafi, yana ba da bege ga marasa lafiya waɗanda ba su amsa maganin gargajiya ba. Binciken, wanda ya bi ƙa'idodin ɗabi'a masu tsauri kuma ya sami amincewa daga Kwamitin Ɗabi'ar Asibitin Lu Daopei, ya jaddada rawar da asibitin ke takawa wajen jagorantar bincike mai ƙirƙira a cikin magungunan ƙwayoyin cuta na CAR-T.

Da wannan ci gaba, Cibiyar Nazarin Hematology ta Lu Daopei ta ci gaba da kafa sabbin fannoni a fannin binciken likitanci, tana samar da hanyoyin magance cututtuka na zamani da kuma inganta sakamakon marasa lafiya. Wannan ci gaban shaida ce ta sadaukarwa da ƙwarewar ƙungiyoyin likitoci da bincike na Asibitin Lu Daopei.