Te Whai Huatanga Ārai Puku Whakarei ake o ngā Pūtau CD19 CAR-T e Hangai Ana ki te 4-1BB i te Maimoatanga i te B-ALL
I roto i tētahi rangahau haumanu nui i whakahaerehia e te Hōhipera o Lu Daopei me te Whare Wānanga o te Hematology o Lu Daopei, kua kitea e ngā kairangahau he huarahi pai ngā pūtau CD19 CAR-T e ahu mai ana i te 4-1BB ki ngā pūtau CAR-T tuku iho e ahu mai ana i te CD28 hei rongoā i te leukemia lymphoblastic acute pūtau B kua hoki mai, kua uaua rānei te rongoā (r/r B-ALL). I whakaatuhia e tēnei rangahau, i uru atu ki ngā rangahau haumanu mua-haumanu me te tūhuratanga pakari, kāore i te whakarato noa i te whai huatanga ārai-pukupuku teitei ake ngā pūtau 4-1BB CAR-T engari he roa ake hoki te mau tonu i roto i ngā tūroro ki te whakataurite ki ō rātou hoa CD28.
I āta whakatauritea e te tīma rangahau o te Hōhipera o Lu Daopei te mahi a ēnei momo pūtau CAR-T e rua. I kitea e rātou, i raro i te tukanga hanga kotahi, he kaha ake te pānga ārai pukupuku o ngā pūtau 4-1BB CAR-T i ngā horopeta iti ake, ā, he iti ake ngā pānga kino kino i puta mai i ngā pūtau CD28 CAR-T. E whakaatu ana ngā hua o te rangahau ko te rongoā CAR-T e ahu mai ana i te 4-1BB ka tuku pea i tētahi kōwhiringa maimoatanga whai hua ake, haumaru ake hoki mō ngā tūroro e pāngia ana e te r/r B-ALL.
E whakaatu ana ēnei kitenga i te whakapau kaha o te Hōhipera o Lu Daopei ki te whakatairanga i te toto me te Te rongoā ārai mate, e tuku ana i te tumanako ki ngā tūroro kāore anō kia aro ki ngā maimoatanga tuku iho. Ko te rangahau, i whai i ngā paerewa matatika pakari, ā, i whakaaetia mai i te Komiti Matatika o te Hōhipera o Lu Daopei, e whakanui ana i te tūranga o te hōhipera ki te ārahi i ngā rangahau auaha i roto i ngā maimoatanga pūtau CAR-T.
Nā tēnei whanaketanga, kei te haere tonu te Lu Daopei Institute of Hematology ki te ārahi i ngā ara hou o te rangahau hauora, me te whakarato i ngā kōwhiringa maimoatanga hou me te whakapai ake i ngā putanga o ngā tūroro. He tohu tēnei whanaketanga i te whakapau kaha me te tohungatanga o ngā tīma hauora me te rangahau o te Hōhipera o Lu Daopei.