Kev Ua Haujlwm Zoo Dua ntawm 4-1BB-Based CD19 CAR-T Cells hauv Kev Kho B-ALL
Hauv kev tshawb fawb tseem ceeb uas tau ua los ntawm Lu Daopei Tsev Kho Mob thiab Lu Daopei Lub Tsev Kawm Ntawv ntawm Hematology, cov kws tshawb fawb tau pom tias 4-1BB-based CD19 CAR-T hlwb muab lwm txoj hauv kev zoo rau CD28-based CAR-T hlwb rau kev kho mob B cell rov qab los yog tsis kho tau (r/r B-ALL). Kev tshawb fawb no, uas muaj kev tshawb fawb ua ntej thiab kev tshawb fawb txog kev kho mob, qhia tau tias 4-1BB CAR-T hlwb tsis yog tsuas yog muab cov txiaj ntsig zoo dua rau kev tiv thaiv kab mob qog nqaij hlav xwb tab sis kuj ua rau cov neeg mob nyob ntev dua piv rau lawv cov CD28 counterparts.
Pawg neeg tshawb fawb ntawm Tsev Kho Mob Lu Daopei tau sib piv cov kev ua tau zoo ntawm ob hom hlwb CAR-T no. Lawv pom tias, nyob rau hauv tib txoj kev tsim khoom, 4-1BB CAR-T hlwb muaj cov nyhuv tiv thaiv qog noj ntshav zoo dua ntawm cov koob tshuaj qis dua thiab ua rau muaj cov xwm txheej tsis zoo tsawg dua li CD28 CAR-T hlwb. Cov txiaj ntsig ntawm kev tshawb fawb qhia tau hais tias kev kho mob CAR-T raws li 4-1BB yuav muab kev xaiv kho mob zoo dua thiab muaj kev nyab xeeb dua rau cov neeg mob uas raug kev txom nyem los ntawm r/r B-ALL.
Cov kev tshawb pom no qhia txog kev cog lus ntawm Lu Daopei Tsev Kho Mob rau kev txhim kho hematology thiab Kev kho mob tiv thaiv kab mob, muab kev cia siab rau cov neeg mob uas tsis tau teb rau cov kev kho mob ib txwm muaj. Txoj kev tshawb fawb no, uas ua raws li cov qauv kev coj ncaj ncees thiab tau txais kev pom zoo los ntawm Lu Daopei Hospital Ethics Committee, hais txog lub luag haujlwm ntawm tsev kho mob hauv kev coj ua txoj kev tshawb fawb tshiab hauv CAR-T cell kev kho mob.
Nrog rau qhov kev tshawb pom no, Lu Daopei Institute of Hematology txuas ntxiv mus ua tus thawj coj tshiab hauv kev tshawb fawb txog kev kho mob, muab cov kev xaiv kho mob tshiab thiab txhim kho cov txiaj ntsig ntawm tus neeg mob. Qhov kev nce qib no yog ib qho pov thawj rau kev mob siab rau thiab kev txawj ntse ntawm Lu Daopei Tsev Kho Mob cov pab pawg kho mob thiab kev tshawb fawb.