Kugwira Ntchito Kwambiri kwa Maselo a CD19 CAR-T Okhala ndi 4-1BB Pochiza B-ALL

Mu kafukufuku wofunikira wachipatala wochitidwa ndi Chipatala cha Lu Daopei ndi Lu Daopei Institute of Hematology, ofufuza apeza kuti maselo a CD19 CAR-T okhala ndi 4-1BB amapereka njira ina yabwino m'malo mwa maselo achikhalidwe a CD28 okhala ndi CAR-T pochiza khansa ya m'magazi ya B cell yomwe yabwereranso kapena yokana (r/r B-ALL). Kafukufukuyu, wokhudza kafukufuku wovuta wachipatala asanachite opaleshoni komanso wofufuza, wasonyeza kuti maselo a 4-1BB CAR-T samangopereka mphamvu yolimbana ndi chotupa komanso amawonetsa kupirira kwa nthawi yayitali mwa odwala poyerekeza ndi maselo ena a CD28.

Gulu lofufuza la Chipatala cha Lu Daopei linayerekeza mosamala momwe maselo awiriwa a CAR-T amagwirira ntchito. Anapeza kuti, pogwiritsa ntchito njira yomweyi yopangira, maselo a 4-1BB CAR-T anali ndi mphamvu yolimbana ndi chotupa pamlingo wochepa ndipo amachititsa kuti pakhale zovuta zochepa kuposa maselo a CD28 CAR-T. Zotsatira za kafukufukuyu zikusonyeza kuti chithandizo cha CAR-T chochokera ku 4-1BB chingapereke njira yothandiza komanso yotetezeka yochizira odwala omwe ali ndi r/r B-ALL.

Zomwe zapezekazi zikugogomezera kudzipereka kwa Chipatala cha Lu Daopei pakupititsa patsogolo maphunziro a magazi ndi Chithandizo cha Immunotherapy, kupereka chiyembekezo kwa odwala omwe sanalandire chithandizo chamankhwala chodziwika bwino. Kafukufukuyu, yemwe adatsatira miyezo yokhwima ya makhalidwe abwino ndipo adalandira chilolezo kuchokera ku Komiti ya Makhalidwe Abwino ya Chipatala cha Lu Daopei, akugogomezera udindo wa chipatalachi potsogolera kafukufuku watsopano mu mankhwala a maselo a CAR-T.

Ndi kupita patsogolo kumeneku, Lu Daopei Institute of Hematology ikupitilizabe kuyambitsa njira zatsopano zofufuzira zachipatala, kupereka njira zamakono zochiritsira komanso kukonza zotsatira za odwala. Kupita patsogolo kumeneku ndi umboni wa kudzipereka ndi luso la magulu azachipatala ndi ofufuza a Chipatala cha Lu Daopei.