Ukusebenza Okuthuthukisiwe Kokulwa Nokuqubuka Kwamaseli E-CD19 CAR-T Asekelwe Ku-4-1BB Ekwelapheni I-B-ALL
Esifundweni esibalulekile sezokwelapha esenziwe yiLu Daopei Hospital kanye neLu Daopei Institute of Hematology, abacwaningi bathole ukuthi amaseli e-CD19 CAR-T asekelwe ku-4-1BB anikeza enye indlela ethembisayo kumaseli e-CAR-T asekelwe ku-CD28 endabuko yokwelapha i-B cell acute lymphoblastic leukemia (r/r B-ALL) ephinde yabuya noma engaphikisi. Lolu cwaningo, oluhilela uphenyo oluqinile lwezokwelapha ngaphambi kokwelashwa nokuhlola, lubonise ukuthi amaseli e-CAR-T angu-4-1BB awagcini nje ngokuhlinzeka ngempumelelo ephezulu yokulwa nomdlavuza kodwa futhi abonisa ukuphikelela isikhathi eside ezigulini uma kuqhathaniswa nabalingani bawo be-CD28.
Ithimba locwaningo leSibhedlela iLu Daopei liqhathanise ngokucophelela ukusebenza kwalezi zinhlobo ezimbili zamaseli e-CAR-T. Bathole ukuthi, ngaphansi kwenqubo efanayo yokukhiqiza, amaseli e-CAR-T angu-4-1BB ayenomphumela onamandla wokulwa nomdlavuza ngemithamo ephansi futhi abangela izehlakalo ezimbi ezimbalwa kunamaseli e-CD28 CAR-T. Imiphumela yocwaningo ikhombisa ukuthi ukwelashwa kwe-CAR-T okusekelwe ku-4-1BB kungase kunikeze inketho yokwelapha ephumelela kakhulu nephephile yeziguli ezihlushwa yi-r/r B-ALL.
Lokhu okutholakele kugcizelela ukuzibophezela kweSibhedlela iLu Daopei ekuthuthukiseni i-hematology kanye Ukwelashwa nge-immunotherapy, okunikeza ithemba ezigulini ezingasabelanga ekwelashweni okuvamile. Ucwaningo, olulandele izindinganiso zokuziphatha eziqinile futhi lwathola imvume evela kwiKomiti Yezokuziphatha Yesibhedlela iLu Daopei, lugcizelela indima yesibhedlela ekuholeni ucwaningo olusha ekwelashweni kwamaseli e-CAR-T.
Ngale ntuthuko, i-Lu Daopei Institute of Hematology iyaqhubeka nokuba yiphayona emikhakheni emisha ocwaningweni lwezokwelapha, ihlinzeka ngezinketho zokwelapha ezisezingeni eliphezulu kanye nokuthuthukisa imiphumela yeziguli. Lokhu kuthuthuka kuwubufakazi bokuzinikela kanye nobuchwepheshe bamaqembu ezokwelapha nabacwaningi aseSibhedlela iLu Daopei.