Nkhani

Pa nkhani yoyamba yachipatala, wodwala wazaka 21 anapambana bwino mavuto a thalassemia kudzera mu njira yapamwamba yopangira majini ya CRISPR. Njira yatsopanoyi ndi yofunika kwambiri pochiza matenda oopsa a magazi monga matenda a sickle cell (SCD) ndi thalassemia.

Pa msonkhano wa ASH 2024 womwe ukubwera, gulu lachipatala la Lu Daopei Hospital lidzapereka zotsatira 13 zofufuza zatsopano, zomwe zikuwonetsa kupita patsogolo kwa hematology ndi kuthekera kwa chithandizo cha CAR-T, ndikutsimikiziranso kudzipereka kwawo pakukweza zotsatira za odwala.

Pambuyo polimbana ndi lymphoma kwa zaka zitatu, mayi wazaka 61 adachira kwathunthu kudzera mu njira yatsopano yochiritsira matenda a CAR-T ku BIOOCUS, kuwonetsa kuthekera kosintha moyo wa mankhwala apamwamba a khansa.

Kupita patsogolo kwaposachedwa mu ukadaulo wa CRISPR/Cas kukukonzanso momwe zinthu zilili pakusintha majini mu kafukufuku wa zamankhwala. Nkhaniyi ikufotokoza momwe imagwiritsidwira ntchito, kuwonetsa kuthekera kwakukulu kochiza matenda a majini, khansa, ndi matenda opatsirana.

Nkhani yodabwitsa ku BIOOCUS ikuwonetsa kusintha kwa chithandizo cha CD7 CAR-T mwa mnyamata wazaka 15 yemwe adachira matenda a T-cell acute lymphoblastic leukemia (T-ALL), zomwe zidapangitsa kuti achotsedwe kwathunthu komanso kuti amuikenso kachiwiri.

Bioocus ikusangalala kulowa nawo Msonkhano wachisanu ndi chiwiri wa Immuno-Gene and Cell Therapy (IGC 2024)! Tikuyembekezera kugwira ntchito limodzi ndi akatswiri apadziko lonse lapansi ndikufufuza njira zatsopano zamabizinesi zomwe zikugwirizana ndi ukadaulo wamakono wa majini ndi ma cell therapy. Pamodzi, tiyeni tipange tsogolo la immunotherapy.

Nkhaniyi ikufotokoza za kafukufuku waposachedwa wokhudza kuthana ndi poizoni wa mankhwala a maselo a CAR-T a B-cell lymphomas. Kafukufukuyu akugogomezera njira zothetsera mavuto wamba monga cytokine release syndrome (CRS) ndi neurotoxicity (ICANS), kuonetsetsa kuti chithandizochi chikugwiritsidwa ntchito bwino.

Kafukufuku waposachedwa akuwonetsa mphamvu ndi chitetezo cha chithandizo cha maselo a CD7 CAR-T pochiza khansa ya m'magazi ya B-cell acute lymphoblastic (B-ALL) yobwereranso kapena yokana matenda ndi T-cell lymphoblastic lymphoma (T-LBL). Kafukufukuyu, wochitidwa ndi BIOOCUS mogwirizana ndi Lu Daopei Hospital, akuwonetsa zotsatira zabwino kwa odwala, zomwe zikupereka njira ina yamphamvu m'malo mwa mankhwala ochiritsira achikhalidwe.

Kafukufukuyu, wofalitsidwa mu Magazini ya Clinical Oncology, ikuwonetsa kuchuluka kwa kuchira kwakukulu kwa odwala omwe adagwiritsa ntchito njira zachikhalidwe zochiritsira, zomwe zikuwonetsa kupita patsogolo kodalirika mu chithandizo cha khansa.

Kafukufuku waposachedwapa akuwonetsa kugwira ntchito bwino kwa chithandizo cha CD7 CAR-T kutsatiridwa ndi njira yachiwiri yopatsirana maselo oyambira a allogeneic hematopoietic (HSCT) mwa odwala omwe ali ndi T-cell acute lymphoblastic leukemia (T-ALL) komanso lymphoblastic lymphoma (LBL), zomwe zikuwonetsa kuthekera kwakukulu kopeza kuchira kwathunthu kwa matenda otsalira (MRD)-negative.

Kafukufuku wodziwika bwino akuwonetsa kupambana kwa nthawi yayitali kwa chithandizo cha maselo a CD19 CAR T pochiza odwala omwe ali ndi khansa ya m'magazi yobwereranso/yosakhazikika (ALL) pambuyo poika maselo oyambira a hematopoietic hematopoietic, zomwe zikupereka chiyembekezo chatsopano mu hematology.

Bioocus ili patsogolo pakupanga mankhwala atsopano a CAR-T. Buku laposachedwa lolembedwa ndi Dr. Chunrong Tong ndi gulu lake ku Lu Daopei Hospital likuwonetsa kupita patsogolo kwakukulu ndi zovuta pakugwiritsa ntchito mankhwala achiwiri a CD19 CAR-T mwa odwala a ana, zomwe zikuwonetsa kudzipereka kwa Bioocus pa chithandizo chatsopano cha khansa.