Bioocus Yapita Patsogolo Pakuchiza Ana Acute Lymphoblastic Leukemia
Chochitika chofunika kwambiri pa chithandizo cha CAR-T, chomwe chadziwika ndi kufalitsidwa kwaposachedwa kwa kafukufuku wotsogola wotsogozedwa ndi Dr. Chunrong Tong ku Lu Daopei Hospital. Kafukufukuyu, wotchedwa "Zokumana nazo ndi Zovuta za Chithandizo cha Maselo a CD19 CAR-T a M'badwo Wachiwiri mu Matenda a Khansa ya M'magazi ya Ana," akupereka kusanthula kwathunthu kwa momwe chithandizo cha maselo a CD19 CAR-T a m'badwo wachiwiri chimagwirira ntchito pochiza khansa ya m'magazi ya ana (ALL).
Kafukufukuyu akugogomezera kuthekera kwatsopano kwa Bioocus's Zamalonda za CAR-T pothana ndi vuto limodzi lovuta kwambiri la magazi mwa ana. Kafukufukuyu akufotokoza bwino zotsatira zachipatala zomwe zapezeka mwa odwala omwe adalandira chithandizochi, zomwe zikuwonetsa kuti pali chiyembekezo chochira. Komabe, akuwonetsanso mavuto akuluakulu, makamaka kuyang'anira matenda oopsa a cytokine release syndrome (CRS) ndi neurotoxicity, zomwe zikadali zofunika kwambiri pakukweza chitetezo cha odwala.
Chithandizo cha Bioocus's CAR-T, chomwe chawonetsedwa mu kafukufukuyu, chimagwiritsa ntchito kapangidwe ka m'badwo wachiwiri komwe kumawonjezera ntchito ya maselo a T motsutsana ndi maselo a khansa omwe amatulutsa antigen ya CD19. Njira imeneyi ndi yofunika kwambiri pothana ndi njira zodzitetezera zomwe nthawi zambiri zimakumana ndi milandu ya ana ALL omwe abwereranso kapena omwe sachira. Zotsatira zomwe zaperekedwa m'bukuli sizimangowonetsa mphamvu yochiritsira ya mankhwala a Bioocus's CAR-T komanso zikugogomezera kufunika kwa luso lopitilira komanso kafukufuku wazachipatala kuti apititse patsogolo njirazi.
Kafukufuku wa Dr. Tong akupereka chidziwitso chofunikira pakugwiritsa ntchito njira zochiritsira za CAR-T ndipo akugwirizana ndi cholinga cha Bioocus chopititsa patsogolo. Chithandizo cha Khansa kudzera mu njira zamakono zamakono za biotechnology. Monga mtsogoleri wapadziko lonse lapansi pa chitukuko cha CAR-T, Bioocus ikupitilizabe kudzipereka kukankhira malire a zomwe zingatheke pochiza khansa, ndi cholinga chachikulu chokweza zotsatira za odwala komanso moyo wabwino.
Pamene Bioocus ikupitirizabe kugwirizana ndi mabungwe azachipatala otsogola monga Lu Daopei Hospital, tikudziperekabe kuthana ndi mavuto omwe apezeka mu kafukufukuyu ndikuwongolera Zogulitsa za CAR-T kuti tiwonjezere chitetezo chawo komanso kugwira ntchito bwino. Kudzipereka kwathu pakuchita bwino komanso kupanga zinthu zatsopano kumatsimikizira kuti tili pamalo abwino otsogolera tsogolo la chithandizo cha khansa.