Bioocus Inofambira Mberi Mukurapa Vana Vane Acute Lymphoblastic Leukemia
Chiitiko chakakosha munyaya yekurapa kweCAR-T, chakaratidzwa nekuburitswa kwechidzidzo chitsva chakatungamirwa naDr. Chunrong Tong kuLu Daopei Hospital. Chidzidzo ichi, chine musoro unoti "Chiitiko Nematambudziko eKurapa Masero eCD19 CAR-T eChizvarwa Chechipiri muPediatric Acute Lymphoblastic Leukemia," chinopa ongororo yakazara yekushanda uye kuchengetedzeka kwekurapa masero eCD19 CAR-T echizvarwa chechipiri mukurapa masero evana acute lymphoblastic leukemia (ALL).
Tsvagiridzo iyi inosimbisa kugona kweBioocus's kugadzira zvinhu zvitsva Chigadzirwa cheCAR-T mukugadzirisa chimwe chezvirwere zvakanyanya kuoma zveropa muvana. Chidzidzo ichi chinotsanangura mhedzisiro yekiriniki yakaonekwa muvarwere vakarapwa uku, zvichiratidza huwandu hwekuregererwa hune tariro. Zvisinei, chinoonawo matambudziko akakomba, kunyanya kutarisira severe cytokine release syndrome (CRS) uye neurotoxicity, izvo zvichiri nzvimbo dzakakosha dzekutarisa mukuvandudza kuchengetedzeka kwevarwere.
Kurapa kweCar-T kwaBioocus, kwakaratidzwa muchidzidzo ichi, kunoshandisa dhizaini yechizvarwa chechipiri iyo inowedzera mashandiro eT-cell kurwisa masero ekenza anogadzira CD19 antigen. Nzira iyi inokosha mukukunda nzira dzekudzivirira dzinowanzoonekwa muzvirwere zvevana ALL zvinodzokera shure kana kuti zvinoramba. Mhedzisiro yakapihwa muchinyorwa chino haingoratidzi chete kugona kwekurapa kwechigadzirwa cheCAR-T cheBioocus asiwo inosimbisa kukosha kwekuvandudza kuenderera mberi uye kutsvagurudza kwekiriniki kuti kunatsiridze kurapwa uku zvakanyanya.
Tsvagiridzo yaDr. Tong inopa ruzivo rwakakosha mukushandiswa kwemishonga yeCAR-T uye inoenderana nebasa raBioocus rekufambira mberi. Kurapa Kenza kuburikidza nemhinduro dzepamusoro dzebiotechnology. Semutungamiri wepasi rose mukuvandudzwa kweCAR-T, Bioocus inoramba yakazvipira kusundira miganhu yezvinogona kuitika mukurapa kenza, nechinangwa chekuvandudza mhedzisiro yevarwere uye mhando yehupenyu.
Sezvo Bioocus ichiramba ichishanda pamwe chete nemasangano makuru ekurapa akaita seLu Daopei Hospital, tinoramba takazvipira kugadzirisa matambudziko akaonekwa muchidzidzo ichi uye kunatsiridza Zvigadzirwa zveCAR-T kuwedzera kuchengetedzeka kwavo uye kushanda kwavo zvakanaka. Kuzvipira kwedu pakuita zvakanaka uye kuvandudza zvinhu kunoita kuti tive panzvimbo yakanaka yekutungamira remangwana rekurapa gomarara.