I-Bioocus Ithuthukisa Umngcele Ekwelapheni I-Acute Lymphoblastic Leukemia Yezingane
Ingqophamlando ebalulekile emkhakheni wokwelashwa kwe-CAR-T, ephawulwe ukushicilelwa kwamuva kocwaningo oluqavile oluholwa nguDkt. Chunrong Tong eSibhedlela iLu Daopei. Lolu cwaningo, olunesihloko esithi "Okuhlangenwe nakho Nezinselele Zokwelashwa Kwamaseli E-CD19 CAR-T Esizukulwaneni Sesibili ku-Pediatric Acute Lymphoblastic Leukemia," lunikeza ukuhlaziywa okuphelele kokusebenza kahle nokuphepha kokwelashwa kwamaseli e-CD19 CAR-T esizukulwaneni sesibili ekwelapheni i-pediatric acute lymphoblastic leukemia (ALL).
Lolu cwaningo lugcizelela amandla amasha e-Bioocus's Umkhiqizo we-CAR-T ekubhekaneni nesinye sezimo ze-hematological eziyinselele kakhulu ezinganeni. Ucwaningo luchaza kabanzi ngemiphumela yezokwelapha ebonwe ezigulini ezithole lokhu kwelashwa, lwembula amazinga okukhululwa athembisayo. Kodwa-ke, luphinde lubone izinselele ezibalulekile, ikakhulukazi ukuphathwa kwe-severe cytokine release syndrome (CRS) kanye nobuthi be-neurotoxicity, okusalokhu kuyizindawo ezibalulekile zokugxila ekuthuthukiseni ukuphepha kweziguli.
Ukwelashwa kwe-CAR-T kwe-Bioocus, okuvezwe kulolu cwaningo, kusebenzisa umklamo wesizukulwane sesibili othuthukisa umsebenzi wamaseli e-T ngokumelene namaseli omdlavuza aveza i-antigen ye-CD19. Le ndlela ibalulekile ekunqobeni izindlela zokumelana ezivame ukutholakala ezimweni ZONKE zezingane ezibuyela emuva noma ezingalapheki. Imiphumela evezwe kulolu shicilelo ayigcini nje ngokugqamisa amandla okwelapha omkhiqizo we-CAR-T we-Bioocus kodwa futhi igcizelela ukubaluleka kokusungula izinto ezintsha okuqhubekayo kanye nocwaningo lwezokwelapha ukuze kuthuthukiswe lezi zindlela zokwelapha.
Ucwaningo lukaDkt. Tong lunikeza ukuqonda okubalulekile ekusetshenzisweni kwezindlela zokwelapha ze-CAR-T futhi luhambisana nomsebenzi we-Bioocus wokuthuthuka. Ukwelashwa Komdlavuza ngokusebenzisa izixazululo ze-biotechnology ezisezingeni eliphezulu. Njengomholi womhlaba wonke ekuthuthukisweni kwe-CAR-T, i-Bioocus isalokhu izibophezele ekucindezeleni imingcele yalokho okungenzeka ekwelapheni umdlavuza, ngenhloso yokugcina yokuthuthukisa imiphumela yeziguli kanye nekhwalithi yokuphila.
Njengoba iBioocus iqhubeka nokusebenzisana nezikhungo zezokwelapha ezihamba phambili njengeLu Daopei Hospital, sisazinikele ekubhekaneni nezinselele ezitholwe kulolu cwaningo nasekuthuthukiseni i- Imikhiqizo ye-CAR-T ukuthuthukisa ukuphepha nokusebenza kahle kwazo. Ukuzibophezela kwethu ekwenzeni kahle nasekusunguleni izinto ezintsha kuqinisekisa ukuthi sisesimweni esihle sokuhola ikusasa lokwelashwa komdlavuza.