I-Bioocus Iqhubela Phambili Umda Ekunyangweni Kwe-Acute Lymphoblastic Leukemia Yabantwana
Isiganeko esibalulekileyo kwicandelo lonyango lwe-CAR-T, esiphawulwe kukupapashwa kutshanje kophando oluphambili olukhokelwa nguGqr. Chunrong Tong kwiSibhedlele saseLu Daopei. Olu phononongo, olunesihloko esithi "Amava kunye nemingeni yoNyango lweeSeli zeCD19 CAR-T zeSizukulwana sesibini kwi-Pediatric Acute Lymphoblastic Leukemia," lubonelela ngohlalutyo olupheleleyo lokusebenza kakuhle kunye nokhuseleko lonyango lweeseli zeCD19 CAR-T zesizukulwana sesibini ekunyangeni i-pediatric acute lymphoblastic leukemia (ALL).
Olu phando lugxininisa amandla okuvelisa izinto ezintsha eBioocus's Imveliso ye-CAR-T ekusombululeni enye yezona meko zinzima kakhulu zegazi ebantwaneni. Olu phononongo luchaza iziphumo zonyango ezibonwe kwizigulana eziye zafumana olu nyango, lutyhila amazinga athembisayo okuxolelwa. Nangona kunjalo, lukwachonga imingeni ebalulekileyo, ingakumbi ulawulo lwe-severe cytokine release syndrome (CRS) kunye ne-neurotoxicity, ezihlala ziindawo eziphambili ekugxilwe kuzo ekuphuculeni ukhuseleko lwezigulana.
Unyango lwe-CAR-T lweBioocus, oluvezwe kolu phononongo, lusebenzisa uyilo lwesizukulwana sesibini oluphucula umsebenzi weeseli ze-T ngokuchasene neeseli zomhlaza ezivelisa i-antigen ye-CD19. Le ndlela ibaluleke kakhulu ekoyiseni iindlela zokuxhathisa ezihlala zifunyanwa kwiimeko ze-ALL zabantwana ezibuyela umva okanye ezingalawulekiyo. Iziphumo ezivezwe kolu shicilelo azibonisi nje kuphela amandla okunyanga emveliso ye-CAR-T yeBioocus kodwa zikwagxininisa ukubaluleka kobuchule obuqhubekayo kunye nophando lweklinikhi ukuze kuphuculwe olu nyango ngakumbi.
Uphando lukaGqr. Tong lunegalelo elibalulekileyo ekusetyenzisweni kwezonyango ze-CAR-T kwaye luhambelana nomsebenzi weBioocus wokuqhubela phambili. Unyango lomhlaza ngokusebenzisa izisombululo ze-biotechnology ezisemgangathweni ophezulu. Njengenkokeli yehlabathi kuphuhliso lwe-CAR-T, iBioocus isazimisele ukutyhala imida yoko kunokwenzeka kunyango lomhlaza, ngenjongo yokugqibela yokuphucula iziphumo zesigulana kunye nomgangatho wobomi.
Njengoko iBioocus iqhubeka nokusebenzisana namaziko ezonyango aphambili afana neSibhedlele iLu Daopei, sisazinikele ekusombululeni imingeni echongiweyo kolu phononongo nasekuphuculeni Iimveliso ze-CAR-T ukuphucula ukhuseleko kunye nokusebenza kwazo. Ukuzinikela kwethu ekugqweseni nasekuveliseni izinto ezintsha kuqinisekisa ukuba sikulungele ukukhokela ikamva lonyango lomhlaza.