Ngā Pūrongo

I roto i tētahi kēhi haumanu hou, i angitu te wikitoria o tētahi tūroro 21-tau te pakeke i ngā wero o te thalassemia mā te whakamahi i tētahi rongoā ira matatau e hangai ana ki te CRISPR. He tohu nui tēnei huarahi auaha i roto i te rongoā i ngā mate toto kino pērā i te mate pūtau toto marino (SCD) me te thalassemia.

I te huihuinga ASH 2024 e tū mai nei, ka whakaatuhia e te tīma hauora o te Hōhipera o Lu Daopei ngā kitenga rangahau hou e 13, e whakaatu ana i ngā whanaketanga i roto i te toto me te kaha o te rongoā CAR-T, e whakaū ana i tā rātou whakapau kaha ki te whakapai ake i ngā putanga o ngā tūroro.

I muri i te whawhai ki te lymphoma mō ngā tau e toru, i tutuki i tētahi wahine 61-tau te murunga katoa mā te rongoā CAR-T takirua auaha i BIOOCUS, e whakaatu ana i te pūmanawa whakarerekētanga o te ao o ngā maimoatanga matepukupuku matatau.

Kei te hurihia te āhua o te whakatika ira i roto i ngā rangahau hauora e ngā whanaketanga hou o te hangarau CRISPR/Cas. Ka tūhuratia e tēnei tuhinga ōna tono, e whakaatu ana i te pūmanawa nui mō te rongoā i ngā mate ira, ngā mate pukupuku, me ngā mate pāwera.

E whakaatu ana tētahi take whakamiharo i BIOOCUS i te pānga whakarerekētanga o te rongoā CD7 CAR-T i roto i tētahi tamaiti 15-tau te pakeke me te mate T-cell acute lymphoblastic leukemia (T-ALL), ā, i mutu katoa te mahi me te angitu o te whakawhitinga tuarua.

Kei te harikoa a Bioocus ki te whakauru atu ki te 8 o ngā Huihuinga Immuno-Gene and Cell Therapy (IGC 2024)! Kei te tumanako mātou ki te mahi tahi me ngā tohunga o te ao, me te tūhura i ngā tauira pakihi hou e rite ana ki ngā hangarau ira me te pūtau hou. Kia mahi tahi tātou ki te hanga i te heke mai o te immunotherapy.

E whakaatu ana tēnei tuhinga pūrongo i ngā rangahau hou mō te whakahaere i ngā paitini o te rongoā pūtau CAR-T mō ngā lymphoma pūtau-B. E aro nui ana te rangahau ki ngā rautaki hei whakahaere i ngā pānga taha noa pēnei i te cytokine release syndrome (CRS) me te neurotoxicity (ICANS), kia pai ake ai te whakamahinga o tēnei rongoā hou.

E whakaatu ana te rangahau hou i te whai huatanga me te haumaru o te rongoā pūtau CD7 CAR-T ki te rongoā i te mate leukemia lymphoblastic acute pūtau-B (B-ALL) me te lymphoma lymphoblastic pūtau-T (T-LBL) kua hoki mai anō, kua uaua rānei te rongoā. Nā BIOOCUS i whakahaere tahi me te Hōhipera o Lu Daopei, e whakaatu ana te rangahau i ngā hua whai hua mō ngā tūroro, e tuku ana i tētahi huarahi kē atu ki te chemotherapy tuku iho.

Ko te rangahau, i whakaputaina i roto i te Te Pukapuka o te Matepukupuku Hauora, e whakaatu ana i ngā reiti murunga nui i roto i ngā tūroro kua pau katoa ngā huarahi maimoatanga tuku iho, he tohu tēnei i te ahunga whakamua pai i roto i te rongoā mate pukupuku.

E whakaatu ana tētahi rangahau hou i te whai huatanga o te rongoā CD7 CAR-T, ā, muri iho ko te whakawhitinga pūtau take hematopoietic allogeneic tuarua (HSCT) i roto i ngā tūroro e pāngia ana e te mate toto nui lymphoblastic acute T-cell (T-ALL) me te lymphoma lymphoblastic (LBL), e whakaatu ana i te kaha nui ki te whakatutuki i te murunga katoa iti rawa o te mate toenga (MRD).

E whakaatu ana tētahi rangahau hou i te angitu roa o te rongoā pūtau-T CD19 CAR i roto i te rongoā i ngā tūroro e pāngia ana e te mate pukupuku toto lymphoblastic acute (ALL) whai muri i te whakawhitinga pūtau take hematopoietic allogeneic, ā, he tumanako hou tēnei i roto i te hematology.

Kei mua a Bioocus i te whakawhanake i ngā rongoā CAR-T o te whakatupuranga hou. Ko te pukapuka hou nā Tākuta Chunrong Tong me tana tīma i te Hōhipera o Lu Daopei e whakaatu ana i ngā whanaketanga nui me ngā wero i roto i te whakamahinga o ngā rongoā CD19 CAR-T o te whakatupuranga tuarua i roto i ngā tūroro tamariki, e whakaatu ana i te whakapau kaha a Bioocus ki te maimoatanga mate pukupuku auaha.