He Whakaora Hou ki te Ao: He Piriti Angitu mō te CD7 CAR-T hei Whakatō i te Pona mō te Tamariki 15-Tau te pakeke me te T-ALL e Hoki Ana

I te 15 noa iho o ōna tau, i hurihia te ao o tētahi tamaiti i te kitenga he mate T-cell acute lymphoblastic leukemia (T-ALL), he maha ngā maimoatanga uaua me ngā raruraru i puta. Ahakoa i whai i te chemotherapy me te whakawhitinga pūtau take allogeneic, i tūpono ia ki te hokinga wawe me ngā raruraru. Heoi, nā te whakapau kaha o tōna whānau me te tohungatanga o te tīma hauora i BIOOCUS, i whiwhi ia i te rongoā CD7 CAR-T, ā, i te mutunga ka puta he whakawhitinga tuarua hei whakaora i tōna ora.

I te marama o Tīhema 2020 i kitea tuatahitia ai te mate, ā, i muri i ngā maimoatanga chemotherapy maha, ka ora katoa te tūroro. Heoi, e toru marama noa iho i muri i te whakawhitinga o te pūtau, ka hoki anō tōna mate, ā, ka nui haere anō hoki te pānga o te pūnaha io matua. Kāore i whai hua ngā maimoatanga paerewa, ā, ka waiho te whānau kia rapu huarahi kē atu.

I te marama o Oketopa 2021, i whakaurua te tūroro ki BIOOCUS, ā, i reira ka whiwhi ia i ētahi atu rongoā chemotherapy hei whakaiti i te taumahatanga o te pukupuku i mua i te rongoātanga ki ngā pūtau CD7 CAR-T. Engari, kāore i angitu te nganatanga tuatahi ki te CAR-T, ā, ka whakaarohia e te tīma hauora te whakamātautau haumanu e haere tonu ana mō te rongoā CD7 whānui CAR-T.

He nui ngā painga o te rongoā CAR-T whānui, tae atu ki te kaha ki te whakamahi i ngā pūtau-T i ahu mai i ngā kaituku hauora, kia tere ake ai te uru atu ki te maimoatanga me te kore e hiahiatia he whakaritenga whaiaro. He mea nui tēnei mō te tūroro, he nui te taumaha o te pukupuku, ā, kāore i taea te whakarato i ngā pūtau e ranea ana mō te rongoā CAR-T tuku iho.

I te 2 o Hakihea, 2021, i whiwhi te tūroro i ngā pūtau CD7 whānui CAR-T. Whai muri i te maimoatanga, i tūtaki tuatahi ia ki ngā wero, tae atu ki te kirika me te ngenge. Heoi, nā te tiaki tautoko, i tau tōna āhua, ā, i whakaatuhia e ngā aromatawai whai muri he whakaoranga whakamiharo, kāore he tohu o te mate toenga iti (MRD).

Whai muri i tēnei maimoatanga angitu, i tukuna te whakawhitinga tuarua ki te tūroro, ā, i pai te haere. Ināianei, tata ki te toru tau i muri mai, kei te ora pai ia, kei te hoki anō ki ngā mahi o ia rā, me te koa ki te ao, he mea tino whakamarie i tōna whānau.

E whakanui ana a Tākuta Zhang Xian, te tumuaki o te tari toto i BIOOCUS, i te hiranga o te rongoā CD7 whānui CAR-T hei kōwhiringa nui mō ngā tūroro kāore e taea te whai i ngā maimoatanga tuku iho. E whakaatu ana tēnei take i te heke mai whai hua o ngā rongoā CAR-T ki te rongoā i ngā mate pukupuku pūtau-T, inā koa mō te hunga kua hoki anō te mate pukupuku toto.

I te whanaketanga haere o ngā rangahau, kei te whānui haere tonu te pūmanawa o ngā maimoatanga CAR-T, e tuku ana i te tumanako hou ki ngā tūroro e whawhai ana ki ngā āhuatanga uaua pēnei i te T-ALL. Kei te whakapau kaha tonu a BIOOCUS ki te ārahi i ngā maimoatanga auaha me te whakapai ake i ngā putanga o ngā tūroro mā te rangahau haumanu tonu.

Mō ētahi atu kōrero e pā ana ki ā mātou maimoatanga CAR-T me pēhea e taea ai e rātou te āwhina i a koe, i tētahi rānei o tō whānau, whakapā atu ki a BIOOCUS.