Ubukode bushya ku buzima: Uburyo bwiza bwo kuvura CD7 CAR-T bufasha umwana w'imyaka 15 gutera T-ALL yasubitse

Ku myaka 15 gusa, ubuzima bw'umuhungu bwahindutse cyane nyuma yo gupimwa indwara ya T-cell acute lymphoblastic leukemia (T-ALL), yagaragayemo uburyo butandukanye bwo kuvura no gukomeretsa. Nubwo yagiriwe imiti ya chimiotherapie ndetse aterwa allogeneic stem cells, yahuye n'ibibazo byo kongera kurwara hakiri kare. Ariko, binyuze mu bwitange bw'umuryango we n'ubuhanga bw'itsinda ry'abaganga bo muri BIOOCUS, yahawe ubuvuzi bwa CD7 CAR-T, amaherezo butuma ahabwa ubundi buryo bwo kumukiza.

Yabanje kuvurwa mu Ukuboza 2020, ariko nyuma yo guhabwa imiti myinshi ya chimiotherapie, yasubitse asubira mu buzima bwe, ndetse yongeraho no kuba yari afite ubwo burwayi. Uburyo busanzwe bwo kuvura bwaragaragaye ko ntacyo bumaze, bituma umuryango ushakisha ubundi buryo bwo kuvura.

Mu Ukwakira 2021, umurwayi yakiriwe muri BIOOCUS, aho yahawe indi miti igabanya umutwaro w'ikibyimba mbere yo kuvurwa hakoreshejwe selile za CD7 CAR-T. Ikibabaje ni uko igerageza rya mbere rya CAR-T ryananiwe, bituma itsinda ry'abaganga risuzuma igerageza rikomeje kuvura CD7 universal CAR-T.

Ubuvuzi bwa CAR-T buhuriweho na bose butanga ibyiza bikomeye, birimo ubushobozi bwo gukoresha uturemangingo twa T dukomoka ku baterankunga bazima, bigatuma umuntu abona ubuvuzi bwihuse hatabayeho kwihindurira ku giti cye. Ibi byari ingenzi ku murwayi, wari ufite ikibazo kinini cy’ibibyimba kandi atashoboraga gutanga uturemangingo duhagije two kuvura CAR-T mu buryo busanzwe.

Ku ya 2 Ukuboza 2021, umurwayi yahawe selile za CD7 universal CAR-T. Nyuma yo kuvurwa, yabanje guhura n'ibibazo birimo umuriro n'umunaniro. Ariko, hamwe n'ubufasha bwo kwita ku buzima bwe, ubuzima bwe bwarahagaze neza, kandi isuzuma ryakurikiyeho ryagaragaje ko yakize cyane, nta bimenyetso byerekana ko hari indwara nkeya zisigaye (MRD).

Nyuma y’ubu buvuzi bwiza, umurwayi yatewe ubundi bwoko bw’inyongera, kandi byagenze neza. Ubu, nyuma y’imyaka hafi itatu, arimo aratera imbere, yongeye gukora imirimo isanzwe kandi yishimira ubuzima, ibyo bikaba byarashimishije umuryango we cyane.

Dr. Zhang Xian, umuyobozi w’ishami ry’ubuvuzi bw’amaraso muri BIOOCUS, ashimangira akamaro ko kuvura CD7 universal CAR-T nk'uburyo bw'ingenzi ku barwayi badashobora kuvurwa gakondo. Uru rubanza rugaragaza ahazaza heza ho kuvura CAR-T mu kuvura kanseri ya T-cells, cyane cyane ku bafite kanseri ya kanseri yongeye kugaruka.

Uko ubushakashatsi bugenda butera imbere, ubushobozi bwo kuvura bwa CAR-T bukomeje kwiyongera, butanga icyizere gishya ku barwayi bahanganye n'ibibazo bikomeye nka T-ALL. BIOOCUS ikomeje kwiyemeza kuvugurura ubuvuzi no kunoza umusaruro w'abarwayi binyuze mu bushakashatsi bukomeje gukorwa mu buvuzi.

Kugira ngo umenye byinshi ku bijyanye n'ubuvuzi bwacu bwa CAR-T n'uburyo bushobora kugufasha cyangwa kugufasha uwo ukunda, nyamuneka hamagara BIOOCUS.