Lendi Yatsopano pa Moyo: Chithandizo Chopambana cha CD7 CAR-T Chimalumikiza Mwana Wazaka 15 Kuti Asinthe T-ALL Yobwerera M'mbuyo

Ali ndi zaka 15 zokha, moyo wa mnyamata wina unasintha mwadzidzidzi atapezeka ndi matenda a T-cell acute lymphoblastic leukemia (T-ALL), omwe anali ndi njira zosiyanasiyana zochiritsira komanso zovuta. Ngakhale kuti adapatsidwa mankhwala a chemotherapy komanso opaleshoni yoika maselo oyambira a allogeneic, adakumana ndi mavuto ambiri msanga. Komabe, chifukwa cha kudzipereka kwa banja lake komanso luso la gulu lachipatala ku BIOOCUS, adalandira chithandizo cha CD7 CAR-T, zomwe pamapeto pake zidamupangitsa kuti alandire chithandizo chachiwiri chopulumutsa moyo.

Poyamba adapezeka ndi matendawa mu Disembala 2020, koma wodwalayo adachira kwathunthu atalandira mankhwala a chemotherapy kangapo. Komabe, patangopita miyezi itatu atapatsidwa chithandizo, adabwereranso ku matenda ake, zomwe zidawonjezera kukhudzidwa kwa mitsempha yapakati. Mankhwala wamba sanagwire ntchito, zomwe zidapangitsa banjali kufunafuna njira zina.

Mu Okutobala 2021, wodwalayo adalowetsedwa ku BIOOCUS, komwe adalandira mankhwala ena ochizira khansa kuti achepetse kuchuluka kwa chotupa asanalandire chithandizo ndi maselo a CD7 CAR-T. Mwatsoka, kuyesa koyamba kwa CAR-T sikunapambane, zomwe zidapangitsa gulu lachipatala kuganizira za kuyesa kwachipatala komwe kukuchitika kwa chithandizo cha CD7 universal CAR-T.

Chithandizo cha CAR-T cha Universal chimapereka ubwino waukulu, kuphatikizapo kuthekera kogwiritsa ntchito maselo a T ochokera kwa opereka athanzi, zomwe zimapangitsa kuti chithandizo chipezeke mwachangu popanda kufunikira kusintha kwapadera. Izi zinali zofunika kwambiri kwa wodwalayo, yemwe anali ndi vuto lalikulu la chotupa ndipo sakanatha kupereka maselo okwanira pa chithandizo chachikhalidwe cha CAR-T.

Pa Disembala 2, 2021, wodwalayo adalandira maselo a CD7 CAR-T. Pambuyo pa chithandizo, poyamba anakumana ndi mavuto, kuphatikizapo malungo ndi kutopa. Komabe, ndi chithandizo chochirikiza, vuto lake linakhazikika, ndipo kuwunika kotsatira kunawonetsa kuti matendawa adachira bwino kwambiri, popanda umboni wa matenda ochepa otsala (MRD).

Pambuyo pa chithandizo chopambanachi, wodwalayo adachitidwa opaleshoni yachiwiri, yomwe idayenda bwino. Tsopano, patatha zaka pafupifupi zitatu, akuyenda bwino, akuyambiranso ntchito zake zachizolowezi ndikusangalala ndi moyo, zomwe zathandiza banja lake kupeza mpumulo.

Dr. Zhang Xian, mkulu wa dipatimenti ya matenda a magazi ku BIOOCUS, akugogomezera kufunika kwa chithandizo cha CD7 universal CAR-T ngati njira yofunika kwambiri kwa odwala omwe sangathe kulandira chithandizo chachikhalidwe. Nkhaniyi ikuwonetsa tsogolo labwino la chithandizo cha CAR-T pochiza khansa ya T-cell, makamaka kwa iwo omwe ali ndi mitundu ina ya khansa ya m'magazi yomwe yabwereranso.

Pamene kafukufuku akupita patsogolo, kuthekera kwa mankhwala a CAR-T kukupitirira kukula, kupereka chiyembekezo chatsopano kwa odwala omwe akulimbana ndi mavuto monga T-ALL. BIOOCUS ikudziperekabe kuyambitsa njira zatsopano zochizira komanso kukonza zotsatira za odwala kudzera mu kafukufuku wamankhwala womwe ukuchitika.

Kuti mudziwe zambiri zokhudza njira zathu zochiritsira za CAR-T komanso momwe zingakuthandizireni inu kapena wokondedwa wanu, chonde lemberani BIOOCUS.