Rendi Itsva paHupenyu: Kurapa kweCD7 CAR-T kwakabudirira kwava pedyo nekuisa mwana mudumbu ane makore gumi nemashanu ekuberekwa neT-ALL yakadzoka mumuviri
Aine makore gumi nemashanu chete ekuberekwa, hupenyu hwemukomana hwakachinja-chinja mushure mekuonekwa aine chirwere cheT-cell acute lymphoblastic leukemia (T-ALL), chakaratidzwa nekurapwa kwakaoma uye zvipingamupinyi zvakawanda. Pasinei nekurapwa nechemotherapy uye kuisirwa masero e allogeneic, akasangana nematambudziko achiri mudiki. Zvisinei, kuburikidza nekuzvipira kwemhuri yake uye neruzivo rwechikwata chekurapa cheBIOOCUS, akagamuchira kurapwa kweCD7 CAR-T, izvo zvakazoita kuti aisirwe kechipiri.
Pakutanga kuongororwa chirwere muna Zvita 2020, murwere wacho akapora zvachose mushure mekupiwa mishonga yakawanda yekurapa. Zvisinei, mwedzi mitatu chete mushure mekuisirwa mushonga, akadzokera kuchirwere, zvichikonzerwa nekubatanidzwa kwetsinga dzemutsinga. Kurapwa kwakajairika hakuna kushanda, zvikaita kuti mhuri itsvage dzimwe nzira dzekurapa.
Muna Gumiguru 2021, murwere akapinda muBIOOCUS, kwaakapihwa mamwe chemotherapy kuderedza mutoro webundu asati arapwa neCD7 CAR-T cells. Zvinosuwisa kuti kuedza kwekutanga kweCAR-T hakuna kubudirira, zvikaita kuti timu yezvekurapa ifunge nezvekuyedzwa kuri kuenderera mberi kwekurapa kweCD7 universal CAR-T.
Kurapa kweCAR-T kwese kune zvakanakira zvikuru, zvinosanganisira kugona kushandisa T-cells dzinobva kune vanopa vane hutano, zvichibvumira kuwana kurapwa nekukurumidza pasina chikonzero chekugadzirisa maitiro avo. Izvi zvaive zvakakosha kumurwere, uyo aive negomarara rakakura uye aisakwanisa kupa masero akakwana ekurapa kweCAR-T kwekare.
Musi wa2 Zvita 2021, murwere akagamuchira maCD7 universal CAR-T cells. Mushure mekurapwa, pakutanga akasangana nematambudziko, anosanganisira fivha nekuneta. Zvisinei, nerubatsiro rwekutarisirwa, mamiriro ake akadzikama, uye kuongororwa kwakatevera kwakaratidza kurerukirwa kunoshamisa, pasina humbowo hwechirwere chidiki (MRD).
Mushure mekurapwa uku kwakabudirira, murwere akavhiyiwa kechipiri, izvo zvakafamba zvakanaka. Iye zvino, makore angangoita matatu gare gare, ari kubudirira, achitangazve mabasa ake enguva dzose uye achinakidzwa nehupenyu, zvichifadza mhuri yake zvikuru.
Dr. Zhang Xian, mukuru wedhipatimendi rekuongorora ropa paBIOOCUS, anosimbisa kukosha kwekurapa kweCD7 universal CAR-T senzira yakakosha kune varwere vasingakwanise kurapwa kwechivanhu. Nyaya iyi inoratidza ramangwana rine tariro rekurapa kweCAR-T mukurapa kenza yeT-cell, kunyanya kune avo vane kenza yeropa yakadzoka.
Sezvo tsvakurudzo ichifambira mberi, mukana wekurapa kweCAR-T uri kuramba uchikura, zvichipa tariro itsva kuvarwere vari kutarisana nematambudziko akaoma seT-ALL. BIOOCUS ichiri kuzvipira kutanga kurapwa kutsva uye kuvandudza mhedzisiro yevarwere kuburikidza nekutsvagisa kuri kuitwa mukiriniki.
Kuti uwane rumwe ruzivo nezvemishonga yedu yeCAR-T uye kuti ingakubatsira sei iwe kana mudiwa wako, ndapota taura neBIOOCUS.