Isivumelwano Esisha Sokuqasha Empilweni: Ukwelashwa Okuphumelelayo Kwe-CD7 CAR-T Kuhlanganisa Ukufakelwa Kwesitshalo Komntwana Oneminyaka Engu-15 Ono-T-ALL Ophinde Wabuyela Emsebenzini
Eneminyaka engu-15 nje kuphela ubudala, impilo yomfana yashintshashintsha ngenxa yokuxilongwa kwe-T-cell acute lymphoblastic leukemia (T-ALL), okwaphawulwa uchungechunge lwezindlela zokwelapha eziyinselele kanye nezithiyo. Naphezu kokwelashwa ngamakhemikhali kanye nokufakelwa i-allogeneic stem cell, wabhekana nokubuyela emuva kusenesikhathi kanye nezinkinga. Kodwa-ke, ngokuzinikela komndeni wakhe kanye nobuchwepheshe bethimba lezokwelapha e-BIOOCUS, wathola ukwelashwa kwe-CD7 CAR-T, okwaholela ekufakweni kwesibili okusindisa impilo.
Ekuqaleni kwatholakala ukuthi une-HIV ngoDisemba 2020, isiguli sathola ukuphulukiswa okuphelele ngemva kokwelashwa ngamakhemikhali kaningi. Kodwa-ke, ezinyangeni ezintathu nje ngemva kokufakelwa, saphinde sabhekana nokubuyela emuva, okwaba nomthelela omkhulu ekuhilelekeni kwesistimu yezinzwa ephakathi. Ukwelashwa okujwayelekile kwabonakala kungasebenzi, okwashiya umndeni ufuna ezinye izindlela.
Ngo-Okthoba 2021, isiguli sangeniswa e-BIOOCUS, lapho sathola khona ukwelashwa ngamakhemikhali okwengeziwe ukuze kuncishiswe umthwalo wesimila ngaphambi kokwelashwa ngamaseli e-CD7 CAR-T. Ngeshwa, umzamo wokuqala we-CAR-T awuphumelelanga, okwenza ithimba lezokwelapha licabangele ukuhlolwa okuqhubekayo kokwelashwa kwe-CD7 CAR-T jikelele.
Ukwelashwa kwe-CAR-T okujwayelekile kunikeza izinzuzo ezibalulekile, okuhlanganisa ikhono lokusebenzisa ama-T-cell atholakala kubanikeli abanempilo, okuvumela ukufinyelela okusheshayo ekwelashweni ngaphandle kwesidingo sokwenza ngokwezifiso ngokwezifiso. Lokhu kwakubalulekile esigulini, esasinomthwalo omkhulu wesimila futhi esasingakwazi ukuhlinzeka ngamaseli anele ekwelashweni kwe-CAR-T okujwayelekile.
Ngomhlaka-2 Disemba 2021, isiguli sathola amaseli e-CD7 universal CAR-T. Ngemva kokwelashwa, ekuqaleni sabhekana nezinselele, okuhlanganisa umkhuhlane nokukhathala. Kodwa-ke, ngokunakekelwa okusekelwayo, isimo sakhe sazinza, futhi ukuhlolwa kokulandelela kwembula ukuphulukiswa okuphelele okumangalisayo, kungekho bufakazi besifo esincane esisele (MRD).
Ngemva kwalokhu kwelashwa okuphumelelayo, isiguli saphinde safakelwa ukufakelwa okwesibili, okwahamba kahle. Manje, cishe eminyakeni emithathu kamuva, siyachuma, siqala kabusha imisebenzi evamile futhi sijabulela impilo, okwenze umndeni waso wakhululeka.
UDkt. Zhang Xian, inhloko yomnyango we-hematology e-BIOOCUS, ugcizelela ukubaluleka kokwelashwa kwe-CD7 universal CAR-T njengendlela ebalulekile yeziguli ezingakwazi ukuthola ukwelashwa kwendabuko. Leli cala liqokomisa ikusasa elithembisayo lokwelashwa kwe-CAR-T ekwelapheni umdlavuza we-T-cell, ikakhulukazi kulabo abanezinhlobo ze-leukemia eziphinde zabuya.
Njengoba ucwaningo luqhubeka, amandla okwelashwa kwe-CAR-T ayaqhubeka nokukhula, okunikeza ithemba elisha ezigulini ezibhekene nezimo ezinzima njenge-T-ALL. I-BIOOCUS isalokhu izibophezele ekuqaliseni ukwelashwa okusha kanye nokuthuthukisa imiphumela yeziguli ngocwaningo oluqhubekayo lwezokwelapha.
Ukuze uthole ulwazi olwengeziwe mayelana nokwelashwa kwethu kwe-CAR-T nokuthi kungakusiza kanjani wena noma othandekayo wakho, sicela uxhumane ne-BIOOCUS.