Ngā Pūrongo

I arotakehia e tētahi rangahau whakamuri te auau me ngā pānga o ngā roopu pūmua oligoclonal (APB) i roto i ngā tūroro myeloma maha (MM) kua hoki mai/aukati i rongoatia ki te rongoā LCAR-B38M CAR-T, e whakaatu ana i te hononga o ēnei ki ngā putanga pai ake.

Ko te pakanga rima tau a tētahi tūroro taitamariki e pangia ana e te mate leukemia ki te AML-M2, ā, i mutu ki tētahi whakawhitinga pūtau take haploidentical angitu i te Hōhipera o Lu Daopei, e whakatakoto ana i te ara mō tōna oranga hou hei ākonga whare wānanga.

I roto i tētahi rangahau nui i Haina, i kitea ngā hua pai mō ngā tūroro he mate toto e whakawhitihia ana ki te pūtau take MMUD me te ATG hei ārai i te GVHD.

He tamaiti e iwa marama te pakeke, kua kitea he mate morearea nui te Acute B Lymphoblastic Leukemia (B-ALL), ā, kua whai hua tana whakawhitinga wheua. E rua tau i muri mai, kua ora pai te tamaiti, ā, kua rite hoki mō te kura kōhungahunga.

He arotake tata nei i roto i Te Rongoā Matepukupuku Lancet e whakaatu ana i ngā whanaketanga auaha i roto i te rongoā pūtau CAR-T, e arotahi ana ki te arotau i te tere whakaputa, te whakapai ake i te whai huatanga o te maimoatanga, me te whakawhānui ake i te urunga atu mō ngā tūroro he toto me ngā pukupuku totoka.

He rangahau hou i roto i te Te Pukapuka o te Matepukupuku Hauora E whakaatu ana i ngā hua pai mō te rongoā CD19 CAR-T brexucabtagene autoloucel (brexu-cel) i roto i te rongoā i te mate pukupuku toto lymphoblastic acute pūtau-B kua hoki whakamuri/aukati (R/R B-ALL), e tuku ana i te tumanako mō ngā reiti murunga teitei me te oranga pai ake i roto i ngā taiao o te ao tūturu.

He maha ngā mate o te thalassemia. E tūhuratia ana i roto i tēnei aratohu te alpha me te beta thalassemia, ō rāua take, ō rāua tohu, me ngā kōwhiringa maimoatanga hou e wātea ana i te BIOOCUS International Medical Center.

Whai muri i te tātaritanga mōrearea nui o te mate pukupuku toto-B-lymphoblastic acute me te korenga o te whakawhitinga tuatahi, te āhua nei kāore i tino angitu te ara whakaora o te tūroro. Heoi, nā te tohungatanga o te tīma hauora a Lu Daopei me te whakawhitinga tuarua mai i tētahi kaituku kore whanaunga, kua hoki mai te tumanako me te hauora.

I te 48 o ōna tau, i tino angitu a Jennifer Ficko, i kitea he mate pukupuku wāhanga IV i te mate. Nā roto i ngā maimoatanga hou pēnei i te rongoā TIL me te tautoko pumau a tōna whānau, kua noho kore mate pukupuku ia mō ngā tau e whitu neke atu, e whakanui ana i tana oranga whakamiharo mō ngā tau 14.

I te tau 2016, i kitea he mate pukupuku toto nui (acute T-cell lymphoblastic leukemia) tō te kotiro 11-tau te pakeke, a Wenwen (ingoa karanga). I te aroaro o ngā wero morearea ki te ora, ka tahuri ia me tōna whānau ki te Hōhipera o Lu Daopei mō te maimoatanga. I tēnei rā, whai muri i te whakawhitinga toto angitu me ngā tau o te ora, kei te ora ia, kei te whakarite hoki mō āna whakamātautau whakauru ki te whare wānanga.

Kua puta he whanaketanga hou i roto i te rongoā i te mate pukupuku ate kua pāngia e te mate pukupuku ate kua horapa haere mā te whakakotahitanga o te rongoā pūtau NK, te kano kano DC, me te Nivolumab. I whakaatu tēnei whakakotahitanga o te rongoā ārai mate i te angitu whakamiharo, ā, i hua ake ai te whakaiti nui i te pukupuku me te whakapai ake i te mahi ate i roto noa i ngā wiki e ono mō tētahi tūroro e pangia ana e te mate pukupuku ate kua tata te mutunga.

I te Hui-ā-Tau 29 o Āhia-Moananui-a-Kiwa mō te Whakatō Toto me te Hinu Wai (APBMT), i whakapuaki a Tākuta Lu Peihua i tētahi whaikōrero matua mō te angitu o te rongoā pūtau CAR-T i Haina. I whiwhi mihi o te ao ki ngā raraunga tūturu a tana tīma mai i ngā mahi haumanu, e whakaatu ana i ā rātou takoha ki te rongoā i ngā mate pukupuku toto.