Ngā Hua Whakamiharo o te Whakaora CD7 CAR-T i te Whakakotahitanga me te Whakatō Tuarua i ngā Tūroro T-ALL/LBL kua Hoki Mai
I roto i te rapu tonu ki te whakapai ake i ngā kōwhiringa maimoatanga mō ngā tūroro e pāngia ana e te mate pukupuku toto nui (T-ALL) me te mate pukupuku toto nui (LBL), kua whakaatuhia e tētahi rangahau tata nei ko te whakakotahi i te rongoā CD7 chimeric antigen receptor T cell (CAR-T) me te whakawhitinga pūtau take hematopoietic allogeneic tuarua (HSCT) ka puta he hua pai. I tīmatahia tēnei huarahi auaha i te Hōhipera o Hebei Yanda Lu Daopei me te Hōhipera o Beijing Lu Daopei, i te mahi tahi me Bioocus, ā, i whakaaturia ngā kitenga i te Hui-ā-Tau 65 o te American Society of Hematology (ASH).
I arotahi te rangahau ki te 16 ngā tūroro kua oti kē te HSCT te mahi, ā, kua hoki anō te mate. I whiwhi ēnei tūroro i te rongoā CD7 CAR-T, ā, i hua ake ai he whakatutukitanga whakamiharo 100% o te murunga katoa o te mate MRD-negative i roto i te hinu wheua. I tua atu, i whakaatu hoki te rongoā i te whai huatanga ki te rongoā i ngā whara i waho o te tinana, me te 75% o te auau murunga katoa.
Whai muri i te rongoā CD7 CAR-T, i tukuna he HSCT tuarua ki ngā tūroro. Ko te reiti oranga whānui (OS) mō te tau kotahi he 58.5%, ā, ko te reiti oranga kore-reukemikia (LFS) he 51.4%, e whakaatu ana i te kaha o tēnei rautaki rongoā whakakotahi. E kī ana ngā hua
ko te rongoā CD7 CAR-T, ina whai muri i te HSCT tuarua, he kōwhiringa maimoatanga whai hua pea mō ngā tūroro kua pau kē atu ngā huarahi, ka tukuna atu he whai wāhitanga hou ki te murunga mate mō te wā roa.
E whakaatu ana te rangahau i te kaha o te rongoā CAR-T ki te whakarerekē i te āhua o te maimoatanga mō te T-ALL me te LBL, inā koa mō ngā tūroro kua hoki anō ki te mate i muri i te whakawhitinga tuatahi. Ko te whakaurunga o ngā pūtau CD7 CAR-T, e aro ana ki ngā tohu mate pukupuku motuhake, me te whakawhitinga whai muri, e whakaatu ana i tētahi rautaki kaha ki te whawhai ki ēnei mate pukupuku kaha.
Kei te haere tonu a Bioocus, me te mahi tahi me te Hōhipera o Lu Daopei, ki te tūhura me te whakapai ake i ngā maimoatanga CAR-T hei whakarato i ngā kōwhiringa maimoatanga hou mō ngā mate pukupuku toto. I te whanaketanga o ngā rangahau, ko te tumanako kia pai ake te oranga me te kounga o te oranga mō ngā tūroro e pāngia ana e ēnei mate uaua.
He tohu tēnei rangahau i tētahi taahiraa nui ki mua i roto i te maimoatanga o te T-ALL me te LBL kua hoki anō ki te mate, e whakaatu ana i te kaha o ngā maimoatanga auaha ki te whakarato i ngā putanga pai ake mō ngā tūroro puta noa i te ao.