Iziphumo Ezithembisayo Zonyango Lwe-CD7 CAR-T Ezidityaniswe Nokufakelwa Kwesibini Kwizigulane Ezibuyele Emsebenzini Ze-T-ALL/LBL
Kwiphulo eliqhubekayo lokuphucula iindlela zonyango kwizigulana ezine-T-cell acute lymphoblastic leukemia (T-ALL) ephinde yabuyela kwi-T-cell kunye ne-lymphoblastic lymphoma (LBL), uphando lwakutshanje lubonise ukuba ukudibanisa unyango lwe-CD7 chimeric antigen receptor T-cell (CAR-T) kunye ne-allogeneic hematopoietic stem cell transplantation yesibini (HSCT) kunika iziphumo ezithembisayo. Le ndlela intsha yaqalwa kwiSibhedlele iHebei Yanda Lu Daopei kunye neSibhedlele iBeijing Lu Daopei, ngentsebenziswano neBioocus, kwaye iziphumo zavezwa kwiNtlanganiso yoNyaka yama-65 ye-American Society of Hematology (ASH).
Olu phononongo lujolise kwizigulana ezili-16 ezazikhe zafumana unyango lwe-HSCT ngaphambili zaza zaphinda zabuyela kwisifo. Ezi zigulana zifumene unyango lwe-CD7 CAR-T, nto leyo ekhokelele ekuphumeleleni okumangalisayo kwe-100% ye-MRD-negative complete remission kwi-bone marrow. Ngaphezu koko, unyango lukwabonakalise ukusebenza kakuhle ekunyangeni izilonda ezingaphandle kwe-medullary, nge-75% ye-complement rate.
Emva konyango lwe-CD7 CAR-T, izigulane zenze i-HSCT yesibini. Izinga lokusinda lilonke lonyaka omnye (OS) yayiyi-58.5%, kwaye izinga lokusinda elingenayo i-leukemia (LFS) yayiyi-51.4%, nto leyo ebonisa amandla ale ndlela yonyango edibeneyo. Iziphumo zibonisa ukuba
ukuba unyango lwe-CD7 CAR-T, xa lulandelwa yi-HSCT yesibini, lunokuba lukhetho olufanelekileyo lonyango kwizigulane eziye zazama ezinye iindlela, nto leyo ebanika ithuba elitsha lokufumana ukuphumla ixesha elide.
Olu phononongo lugxininisa amandla onyango lwe-CAR-T ekuguquleni imeko yonyango lwe-T-ALL kunye ne-LBL, ingakumbi kwizigulana eziphinde zabuyela umva emva kokufakelwa isitho sokuqala. Ukuhlanganiswa kweeseli ze-CD7 CAR-T, ezijolise kwiimpawu ezithile zomhlaza, kunye nokufakelwa isitho esilandelayo, kunika icebo elinamandla lokulwa nale mihlaza inamandla.
I-Bioocus, ngokubambisana neSibhedlele iLu Daopei, iyaqhubeka nokuphonononga nokuphucula unyango lwe-CAR-T ukuze ibonelele ngeendlela zonyango oluphambili lwe-hematologic monitors. Njengoko uphando luqhubeka, ithemba kukuphucula ngakumbi amazinga okusinda kunye nomgangatho wobomi kwizigulana ezijongene nezi zifo zinzima.
Olu phononongo lubonisa inyathelo elibalulekileyo eliya phambili kunyango lwe-T-ALL kunye ne-LBL ephinde yabuyela kwisimo sayo, lubonisa amandla onyango olutsha ekunikezeleni iziphumo ezingcono kwizigulana kwihlabathi liphela.