Ingaruka nziza zo kuvura CD7 CAR-T hamwe no gutera ubwa kabiri ku barwayi ba T-ALL/LBL basubijwe mu buzima bwabo
Mu gikorwa cyo kunoza uburyo bwo kuvura abarwayi barwaye kanseri y’amaraso ya T-cell acute lymphoblastic leukemia (T-ALL) na lymphoblastic lymphoma (LBL), ubushakashatsi buherutse gukorwa bwagaragaje ko guhuza uburyo bwo kuvura bwa CD7 chimeric antigen receptor T-cell (CAR-T) hamwe n’uburyo bwa kabiri bwo guteranya uturemangingo tw’amaraso ya allogeneic (HSCT) bitanga umusaruro mwiza. Ubu buryo bushya bwatangijwe mu bitaro bya Hebei Yanda Lu Daopei n’ibitaro bya Beijing Lu Daopei, ku bufatanye na Bioocus, kandi ibyavuye mu bushakashatsi byatanzwe mu nama ngarukamwaka ya 65 y’umuryango w’abanyamerika wita ku maraso (ASH).
Ubushakashatsi bwibanze ku barwayi 16 bari barakorewe HSCT mbere maze bongera gusubira inyuma. Aba barwayi bahawe ubuvuzi bwa CD7 CAR-T, bituma bagera ku 100% ku buremere bwuzuye bwa MRD mu musokoro w'amagufwa. Byongeye kandi, ubu buvuzi bwagaragaje ko bufite akamaro mu kuvura ibisebe byo hanze y'umusokoro, aho igipimo cyo kurekura burundu cya 75%.
Nyuma yo kuvurwa na CD7 CAR-T, abarwayi bakorewe HSCT ya kabiri. Igipimo cy'umwaka umwe cyo kubaho (OS) cyari 58.5%, naho igipimo cy'ubuzima budafite leukemia (LFS) cyari 51.4%, bigaragaza ubushobozi bw'ubu buryo bwo kuvura buhuriweho. Ibisubizo bigaragaza ko hari amahirwe menshi yo kuvura.
ko uburyo bwo kuvura CD7 CAR-T, iyo bukurikiwe na HSCT ya kabiri, bushobora kuba uburyo bwiza bwo kuvura abarwayi bananiwe ubundi buryo, bikabaha amahirwe yo kongera koroherwa mu gihe kirekire.
Ubushakashatsi bugaragaza ubushobozi bwa CAR-T mu guhindura imiterere y’ubuvuzi bwa T-ALL na LBL, cyane cyane ku barwayi basubiye kurwara nyuma yo guterwa ubwa mbere. Guhuza uturemangingo twa CD7 CAR-T, twibanda ku bimenyetso bya kanseri, hamwe no guterwa ubwa nyuma, bitanga ingamba zikomeye zo kurwanya izi kanseri zikomeye.
Bioocus, ku bufatanye n'ibitaro bya Lu Daopei, bakomeje gushakisha no kunoza uburyo bwo kuvura bwa CAR-T kugira ngo batange uburyo bugezweho bwo kuvura kanseri y’amaraso. Uko ubushakashatsi bugenda butera imbere, icyizere ni ukurushaho kunoza urwego rw'ubuzima n'imibereho myiza ku barwayi bahura n'izi ndwara zikomeye.
Ubu bushakashatsi bugaragaza intambwe ikomeye mu kuvura indwara ya T-ALL na LBL yasubitse ku barwayi, bugaragaza ubushobozi bw'ubuvuzi bushya mu gutanga umusaruro mwiza ku barwayi ku isi yose.