Sakamako Mai Kyau Na Maganin CD7 CAR-T Da Aka Haɗa Da Dashen Jiki Na Biyu Ga Marasa Lafiyar T-ALL/LBL Da Suka Lalace

A ci gaba da neman inganta hanyoyin magani ga marasa lafiya da suka sake kamuwa da cutar sankarar jini ta T-cell mai saurin kamuwa da cutar T-cell (T-ALL) da kuma cutar lymphoblastic lymphoma (LBL), wani bincike da aka yi kwanan nan ya nuna cewa hada maganin T-cell na CAR-T na CD7 chimeric antigen receptor tare da dashen ƙwayoyin halitta na allogeneic na biyu (HSCT) yana ba da sakamako mai kyau. An fara wannan sabuwar hanyar a Asibitin Hebei Yanda Lu Daopei da Asibitin Beijing Lu Daopei, tare da haɗin gwiwar Bioocus, kuma an gabatar da sakamakon a taron shekara-shekara na 65 na Ƙungiyar Kula da Cututtuka ta Amurka (ASH).

Binciken ya mayar da hankali kan marasa lafiya 16 waɗanda a baya aka yi musu HSCT kuma suka fuskanci koma-baya. Waɗannan marasa lafiya sun sami maganin CD7 CAR-T, wanda ya haifar da nasarar da aka samu 100% na MRD-negative a cikin ƙashin ƙashi. Bugu da ƙari, maganin ya kuma nuna inganci wajen magance raunukan da ba a cire su ba, tare da kashi 75% na cikakken ragewa.

Bayan maganin CD7 CAR-T, marasa lafiya sun yi gwajin HSCT na biyu. Jimillar rayuwa (OS) na shekara ɗaya shine 58.5%, kuma ƙimar rayuwa ba tare da cutar sankarar bargo ba (LFS) shine 51.4%, wanda ke nuna yuwuwar wannan dabarar magani mai haɗin gwiwa. Sakamakon ya nuna cewa

cewa maganin CD7 CAR-T, idan aka biyo baya da HSCT na biyu, zai iya zama zaɓin magani mai kyau ga marasa lafiya waɗanda suka gaji wasu hanyoyi, yana ba su sabuwar dama a cikin gafara na dogon lokaci.

Binciken ya nuna yuwuwar maganin CAR-T wajen sauya yanayin maganin T-ALL da LBL, musamman ga marasa lafiya da suka sake komawa bayan dashen farko. Haɗa ƙwayoyin CAR-T na CD7, waɗanda ke kai hari ga takamaiman alamun cutar kansa, tare da dashen bayan tiyata, yana gabatar da wata dabara mai ƙarfi don yaƙar waɗannan cututtukan daji masu tsanani.

Bioocus, tare da haɗin gwiwar Asibitin Lu Daopei, suna ci gaba da bincike da kuma inganta hanyoyin magance cututtukan CAR-T don samar da zaɓuɓɓukan magani na zamani don cututtukan jini. Yayin da bincike ke ci gaba, fatan shine a ƙara inganta ƙimar rayuwa da ingancin rayuwa ga marasa lafiya da ke fuskantar waɗannan cututtuka masu ƙalubale.

Wannan binciken ya nuna babban ci gaba a fannin maganin sake kamuwa da cutar T-ALL da LBL, wanda ke nuna yuwuwar sabbin hanyoyin magance cutar wajen samar da sakamako mafi kyau ga marasa lafiya a duk duniya.