Zotsatira Zabwino za Chithandizo cha CD7 CAR-T Chophatikizidwa ndi Kusamutsa Kachiwiri mwa Odwala Obwerera M'mbuyo a T-ALL/LBL
Pakufufuza komwe kukuchitika kokonzanso njira zothandizira odwala omwe ali ndi matenda a T-cell acute lymphoblastic leukemia (T-ALL) komanso lymphoblastic lymphoma (LBL), kafukufuku waposachedwa wasonyeza kuti kuphatikiza chithandizo cha CD7 chimeric antigen receptor T-cell (CAR-T) ndi njira yachiwiri yosinthira maselo a hematopoietic hematopoietic stem cell (HSCT) kumapereka zotsatira zabwino. Njira yatsopanoyi idakhazikitsidwa ku Chipatala cha Hebei Yanda Lu Daopei ndi Chipatala cha Beijing Lu Daopei, mogwirizana ndi Bioocus, ndipo zomwe zapezekazi zidaperekedwa pa Msonkhano Wapachaka wa 65th American Society of Hematology (ASH).
Kafukufukuyu adayang'ana odwala 16 omwe adachitidwapo HSCT kale ndipo adabwereranso kuchipatala. Odwalawa adalandira chithandizo cha CD7 CAR-T, zomwe zidapangitsa kuti 100% ya MRD-negative complete relieve mu bone morrow ifike. Kuphatikiza apo, chithandizochi chidawonetsanso kuti chimagwira ntchito bwino pochiza zilonda zakunja kwa medullary, ndi chiwopsezo cha 75% cha complete relieve.
Pambuyo pa chithandizo cha CD7 CAR-T, odwalawo adapatsidwanso chithandizo chachiwiri cha HSCT. Chiŵerengero cha kupulumuka kwa chaka chimodzi (OS) chinali 58.5%, ndipo chiŵerengero cha kupulumuka kwa anthu opanda leukemia (LFS) chinali 51.4%, zomwe zikusonyeza kuthekera kwa njira yochiritsira yophatikizana iyi. Zotsatira zake zikusonyeza kuti njira yochiritsirayi ingagwiritsidwe ntchito.
kuti chithandizo cha CD7 CAR-T, chikatsatiridwa ndi HSCT yachiwiri, chingakhale njira yabwino yothandizira odwala omwe agwiritsa ntchito njira zina, zomwe zimawapatsa mwayi watsopano wochira kwa nthawi yayitali.
Kafukufukuyu akugogomezera kuthekera kwa chithandizo cha CAR-T kusintha malo ochizira matenda a T-ALL ndi LBL, makamaka kwa odwala omwe abwereranso pambuyo pomuika koyamba. Kuphatikiza maselo a CD7 CAR-T, omwe amalunjika ku zizindikiro za khansa, pamodzi ndi kumuikanso pambuyo pake, kumapereka njira yamphamvu yolimbana ndi khansa yoopsa iyi.
Bioocus, mogwirizana ndi Chipatala cha Lu Daopei, akupitiliza kufufuza ndikusintha njira zochizira matenda a CAR-T kuti apereke njira zamakono zochizira khansa ya m'magazi. Pamene kafukufuku akupita patsogolo, chiyembekezo ndichakuti odwala omwe akukumana ndi matenda ovutawa apulumuke komanso akhale ndi moyo wabwino.
Kafukufukuyu akuwonetsa kupita patsogolo kwakukulu pa chithandizo cha mankhwala obwezeretsa T-ALL ndi LBL, kuwonetsa kuthekera kwa njira zatsopano zochiritsira popereka zotsatira zabwino kwa odwala padziko lonse lapansi.