Mhedzisiro Inovimbisa yeKurapwa kweCD7 CAR-T Yakasanganiswa neKuisirwa Kwechipiri muVarwere Vakadzokera muT-ALL/LBL
Mukutsvaga kuri kuenderera mberi kwekuvandudza nzira dzekurapa varwere vane relapsely T-cell acute lymphoblastic leukemia (T-ALL) uye lymphoblastic lymphoma (LBL), ongororo ichangobva kuitwa yakaratidza kuti kusanganisa CD7 chimeric antigen receptor T-cell (CAR-T) therapy nechipiri allogeneic hematopoietic stem cell transplantation (HSCT) kunopa mhedzisiro yakanaka. Iyi nzira itsva yakatanga kushandiswa paHebei Yanda Lu Daopei Hospital neBeijing Lu Daopei Hospital, pamwe chete neBioocus, uye zvakawanikwa zvakapihwa paMusangano weGore we65th American Society of Hematology (ASH).
Chidzidzo ichi chakanyanya kutarisa pavarwere gumi nevatanhatu vakambobatwa neHSCT uye vakadzokera shure. Varwere ava vakapihwa CD7 CAR-T therapy, zvikaita kuti pave nekubudirira kukuru kwe100% kweMRD-negative complete relieval mubone marrow. Uyezve, kurapa uku kwakaratidzawo kushanda zvakanaka mukurapa maronda ari kunze kwemedullary, ne75% complete relieval rate.
Mushure mekurapwa neCD7 CAR-T, varwere vakaongororwazve kechipiri. Huwandu hwegore rimwe chete hwekurarama (OS) hwaive 58.5%, uye huwandu hwekurarama pasina leukemia (LFS) hwaive 51.4%, zvichiratidza kugona kweiyi nzira yekurapa yakabatana. Mhedzisiro yacho inoratidza kuti
kuti kurapwa neCD7 CAR-T, kana kuchizoteverwa neHSCT yechipiri, kunogona kuva nzira inoshanda yekurapa varwere vakaedza dzimwe nzira, zvichivapa mukana wekuzorora kwenguva refu.
Chidzidzo ichi chinosimbisa mukana wekurapa kweCAR-T mukushandura mamiriro ekurapa kweT-ALL neLBL, kunyanya kune varwere vakadzokera shure mushure mekuisirwa kekutanga. Kubatanidzwa kwemasero eCD7 CAR-T, ayo anotarisa zviratidzo zvegomarara, pamwe chete nekuisirwa kechipiri, kunopa nzira yakasimba yekurwisa magomarara aya ane simba.
Bioocus, pamwe chete neLu Daopei Hospital, vari kuramba vachiongorora nekugadzirisa nzira dzekurapa dzeCAR-T kuti vape nzira dzekurapa dzemhando yepamusoro dzezvirwere zveropa. Sezvo tsvakurudzo ichienderera mberi, tariro ndeyekuvandudza huwandu hwevanhu vanorarama uye hupenyu hwakanaka hwevarwere vari kutarisana nezvirwere izvi zvakaoma.
Chidzidzo ichi chinoratidza danho rakakosha mukurapa kweT-ALL neLBL dzakadzoka, zvichiratidza mukana wekurapa kutsva mukupa mhedzisiro iri nani kuvarwere pasi rese.