Imiphumela Ethembisayo Yokwelashwa Kwe-CD7 CAR-T Okuhlanganiswe Nokufakelwa Kwesibili Ezigulini Ezibuyele Emuva Ze-T-ALL/LBL
Emizamweni eqhubekayo yokuthuthukisa izinketho zokwelapha zeziguli ezine-T-cell acute lymphoblastic leukemia (T-ALL) ephinde yatholakala kanye ne-lymphoblastic lymphoma (LBL), ucwaningo lwamuva nje lukhombisile ukuthi ukuhlanganisa ukwelashwa kwe-CD7 chimeric antigen receptor T-cell (CAR-T) kanye nokufakelwa kwesibili kwe-allogeneic hematopoietic stem cell (HSCT) kunikeza imiphumela ethembisayo. Le ndlela entsha yasungulwa eSibhedlela iHebei Yanda Lu Daopei kanye naseSibhedlela iBeijing Lu Daopei, ngokubambisana neBioocus, kanti okutholakele kwethulwe eMhlanganweni Waminyaka Yonke we-65th American Society of Hematology (ASH).
Ucwaningo lugxile ezigulini ezingu-16 ezazike zathola i-HSCT futhi zaphinde zabhekana nokubuyela emuva. Lezi ziguli zathola ukwelashwa kwe-CD7 CAR-T, okwaholela ekufinyeleleni okuphawulekayo okungu-100% kokukhululwa okuphelele kwe-MRD-negative emnkantsheni wethambo. Ngaphezu kwalokho, ukwelashwa kubonise nokusebenza kahle ekwelapheni izilonda zangaphandle kwe-medullary, ngesilinganiso sokukhululwa okuphelele esingu-75%.
Ngemva kokwelashwa nge-CD7 CAR-T, iziguli zithole i-HSCT yesibili. Izinga lokusinda okuphelele konyaka owodwa (OS) lalingu-58.5%, kanti izinga lokusinda okungenalo i-leukemia (LFS) lalingu-51.4%, okugqamisa amandla aleli qhinga lokwelapha elihlanganisiwe. Imiphumela isikisela ukuthi
ukuthi ukwelashwa kwe-CD7 CAR-T, uma kulandelwa i-HSCT yesibili, kungaba yindlela yokwelapha esebenzayo yeziguli esezisebenzise ezinye izindlela, ezizinikeza ithuba elisha lokuphumula isikhathi eside.
Lolu cwaningo lugcizelela amandla okwelashwa kwe-CAR-T ekuguquleni isimo sokwelashwa kwe-T-ALL kanye ne-LBL, ikakhulukazi ezigulini eziphinde zabuyela esimweni sazo ngemva kokufakelwa kokuqala. Ukuhlanganiswa kwamaseli e-CD7 CAR-T, ahlose izimpawu ezithile zomdlavuza, kanye nokufakelwa okulandelayo, kuveza isu elinamandla lokulwa nalezi zinhlayiya ezinolaka.
I-Bioocus, ngokubambisana neSibhedlela iLu Daopei, iyaqhubeka nokuhlola nokuthuthukisa izindlela zokwelapha ze-CAR-T ukuze inikeze izinketho zokwelapha ezisezingeni eliphezulu zezifo zegazi. Njengoba ucwaningo luqhubeka, ithemba ukuthuthukisa amazinga okusinda kanye nekhwalithi yokuphila kweziguli ezibhekene nalezi zifo eziyinselele.
Lolu cwaningo luphawula isinyathelo esibalulekile ekwelapheni i-T-ALL kanye ne-LBL ephinde yabuya, okubonisa amandla okwelashwa okusha ekuletheni imiphumela engcono ezigulini emhlabeni jikelele.