Xov xwm

Hauv ib rooj plaub kho mob uas tau tsim kho tshiab, ib tug neeg mob hnub nyoog 21 xyoo tau kov yeej cov teeb meem ntawm thalassemia los ntawm kev siv CRISPR-based gene therapy. Txoj kev tshiab no yog ib qho tseem ceeb hauv kev kho cov kab mob ntshav hnyav xws li kab mob sickle cell (SCD) thiab thalassemia.

Ntawm lub rooj sib tham ASH 2024 uas yuav los txog no, pab pawg kho mob ntawm Lu Daopei Tsev Kho Mob yuav nthuav tawm 13 qhov kev tshawb pom tshiab, qhia txog kev nce qib hauv kev kho mob ntshav thiab lub peev xwm ntawm kev kho mob CAR-T, rov lees paub lawv txoj kev cog lus los txhim kho cov txiaj ntsig ntawm tus neeg mob.

Tom qab tawm tsam lymphoma tau peb xyoos, ib tug poj niam hnub nyoog 61 xyoo tau txais kev zam txim tag nrho los ntawm kev kho mob CAR-T ob zaug ntawm BIOOCUS, qhia txog lub peev xwm hloov pauv lub neej ntawm kev kho mob qog noj ntshav siab heev.

Cov kev nce qib tshiab hauv CRISPR/Cas thev naus laus zis tab tom hloov kho qhov xwm txheej ntawm kev kho cov noob caj noob ces hauv kev tshawb fawb biomedical. Tsab xov xwm no tshawb nrhiav nws cov ntawv thov, qhia txog lub peev xwm tseem ceeb rau kev kho cov kab mob caj ces, mob qog noj ntshav, thiab cov kab mob sib kis.

Ib rooj plaub zoo kawg nkaus ntawm BIOOCUS qhia txog qhov cuam tshuam ntawm CD7 CAR-T kev kho mob hauv ib tug tub hluas hnub nyoog 15 xyoo uas muaj tus kab mob T-cell acute lymphoblastic leukemia (T-ALL) rov qab los, ua rau nws zoo tag nrho thiab ua tiav kev hloov pauv zaum ob.

Bioocus zoo siab koom nrog lub rooj sib tham txog kev kho mob immuno-Gene thiab Cell Therapy Congress thib 8 (IGC 2024)! Peb tos ntsoov yuav koom tes nrog cov kws tshaj lij thoob ntiaj teb thiab tshawb nrhiav cov qauv lag luam tshiab uas phim cov thev naus laus zis kho mob gene thiab cell tshiab. Ua ke, cia peb tsim lub neej yav tom ntej ntawm kev kho mob immunotherapy.

Tsab xov xwm no qhia txog kev tshawb fawb tsis ntev los no txog kev tswj hwm cov tshuaj lom ntawm CAR-T cell therapy rau B-cell lymphomas. Kev tshawb fawb no hais txog cov tswv yim los daws cov teeb meem tshwm sim xws li cytokine release syndrome (CRS) thiab neurotoxicity (ICANS), kom ntseeg tau tias kev siv txoj kev kho mob tshiab no muaj kev nyab xeeb dua.

Cov kev tshawb fawb tshiab tshaj plaws qhia txog qhov ua tau zoo thiab kev nyab xeeb ntawm CD7 CAR-T cell therapy hauv kev kho mob B-cell acute lymphoblastic leukemia (B-ALL) thiab T-cell lymphoblastic lymphoma (T-LBL). Ua los ntawm BIOOCUS ua ke nrog Lu Daopei Tsev Kho Mob, kev tshawb fawb qhia txog cov txiaj ntsig zoo rau cov neeg mob, muab lwm txoj hauv kev zoo rau kev kho mob chemotherapy.

Txoj kev tshawb fawb, luam tawm hauv Phau Ntawv Xov Xwm Txog Kev Kho Mob Oncology, qhia tau tias cov neeg mob uas tau siv tag nrho cov kev kho mob ib txwm muaj los ntawm kev zam txim, uas yog ib qho kev vam meej zoo hauv kev kho mob qog noj ntshav.

Tsis ntev los no, kev tshawb fawb qhia txog qhov ua tau zoo ntawm CD7 CAR-T kev kho mob ua raws li qhov thib ob allogeneic hematopoietic stem cell transplantation (HSCT) rau cov neeg mob uas rov qab mob T-cell acute lymphoblastic leukemia (T-ALL) thiab lymphoblastic lymphoma (LBL), qhia txog lub peev xwm tseem ceeb hauv kev ua tiav qhov tsawg kawg nkaus ntawm cov kab mob seem (MRD)-negative complete remission.

Ib txoj kev tshawb fawb tshiab qhia txog kev vam meej mus sij hawm ntev ntawm CD19 CAR T-cell kev kho mob hauv kev kho cov neeg mob uas rov qab mob/tsis khov kho mob hlwb (ALL) tom qab kev hloov hlwb hlwb allogeneic hematopoietic, muab kev cia siab tshiab hauv kev kho mob ntshav.

Bioocus yog tus thawj coj hauv kev tsim cov kev kho mob CAR-T tiam tom ntej. Cov ntawv tshaj tawm tsis ntev los no los ntawm Dr. Chunrong Tong thiab nws pab neeg ntawm Lu Daopei Tsev Kho Mob qhia txog kev nce qib tseem ceeb thiab kev cov nyom hauv kev siv cov kev kho mob CD19 CAR-T tiam thib ob rau cov menyuam yaus, qhia txog Bioocus txoj kev cog lus rau kev kho mob qog noj ntshav tshiab.