Kev Siv CD7 CAR-T Kho Mob Zoo Rau B-Cell Malignancies: Kev Kho Mob Cancer Zoo Tshaj Plaws
Cov kev tshawb fawb tshiab tshaj plaws qhia txog qhov ua tau zoo thiab kev nyab xeeb ntawm CD7 CAR-T cell therapy hauv kev kho mob B-cell acute lymphoblastic leukemia (B-ALL) thiab T-cell lymphoblastic lymphoma (T-LBL). Ua los ntawm BIOOCUS ua ke nrog Lu Daopei Tsev Kho Mob, kev tshawb fawb qhia txog cov txiaj ntsig zoo rau cov neeg mob, muab lwm txoj hauv kev zoo rau kev kho mob chemotherapy.
Hauv kev loj hlob zoo siab rau Kev Kho Mob Cancer, BIOOCUS, koom tes nrog Lu Daopei Tsev Kho Mob, tau tshaj tawm cov kev tshawb fawb tshiab txog kev siv CD7 chimeric antigen receptor (CAR) T-cell therapy. Txoj hauv kev tshiab no, tsom mus rau relapsed lossis refractory B-cell acute lymphoblastic leukemia (B-ALL) thiab T-cell lymphoblastic lymphoma (T-LBL), qhia txog kev ua haujlwm zoo thiab kev nyab xeeb, txhim kho cov txiaj ntsig ntawm tus neeg mob.
Txoj kev tshawb fawb no, luam tawm hauv ib phau ntawv xov xwm muaj koob npe nrov, suav nrog kev sib piv cov neeg mob uas tau txais kev kho mob CD7 CAR-T ua raws li kev sib koom ua ke nrog allogeneic hematopoietic stem cell transplantation (allo-HSCT) piv rau cov neeg uas tau kho nrog chemotherapy ua ntej hloov pauv. Cov ntaub ntawv tshawb fawb qhia tau tias cov neeg mob uas tau txais kev zam txim tag nrho (CR) nrog CD7 CAR-T kev kho mob muaj cov txiaj ntsig ciaj sia ntev zoo sib xws rau cov neeg uas tau kho nrog chemotherapy ib txwm muaj. Qhov tseem ceeb, txoj kev tshawb fawb pom tsis muaj kev nce ntxiv ntawm cov teeb meem tom qab hloov pauv, xws li kab mob graft-versus-host (GVHD), kev kis kab mob, lossis lwm yam xwm txheej tsis zoo.
Cov ntsiab lus tseem ceeb ntawm txoj kev tshawb fawb suav nrog:
- Tus Nqi Kev Zam Txim Tag Nrho: Kev kho mob CD7 CAR-T tau qhia txog tus nqi zoo kawg nkaus, nrog rau ntau dua 97% ntawm cov neeg mob teb zoo rau kev kho mob.
- Cov Ntaub Ntawv Kev Nyab Xeeb: Txawm hais tias muaj txoj kev kho mob tshiab los ntawm kev siv CAR-T, kev kho mob no tau txais kev pom zoo, muaj cov kev mob tshwm sim tsawg heev thiab tsis muaj kev nce ntxiv ntawm GVHD qib siab lossis lwm yam teeb meem loj.
- Kev Ua Tau Zoo Tom Qab Hloov Pauv: Cov neeg mob uas tau txais allo-HSCT tom qab ua tiav CR nrog CD7 CAR-T kev kho mob tau muaj kev ciaj sia zoo (OS) thiab kev ciaj sia tsis muaj leukemia (LFS), sib piv rau cov kev kho mob chemotherapy ib txwm muaj.
Qhov kev tshawb nrhiav no yog ib qho tseem ceeb hauv kev tshawb nrhiav txog kev lag luam Kev Kho Mob Cancer Immunotherapy, muab kev cia siab rau cov neeg mob uas rov qab mob lossis tsis kho tau cov kab mob leukemia thiab lymphoma. BIOOCUS tseem cog lus tias yuav txhim kho cov ciam teb ntawm kev kho mob CAR-T, muab cov kev daws teeb meem tshiab rau cov neeg mob uas tau siv cov kev kho mob ib txwm muaj. Thaum lub ntiaj teb lees txais cov kev kho mob tshiab no, BIOOCUS yog tus thawj coj hauv kev tsim cov kev kho mob uas coj kev hloov pauv tiag tiag rau cov txiaj ntsig ntawm tus neeg mob.