Ka Pono Kiʻekiʻe o ka CD7 CAR-T Therapy no nā Malignancies B-Cell: He Huakaʻi Hou i ka Lapaʻau ʻana i ka Maʻi Kanesa
Hōʻike ka noiʻi hou loa i ka pono a me ka palekana o ka lāʻau lapaʻau CD7 CAR-T cell i ka mālama ʻana i ka relapsed a refractory B-cell acute lymphoblastic leukemia (B-ALL) a me T-cell lymphoblastic lymphoma (T-LBL). Hana ʻia e BIOOCUS me ka laulima ʻana me ka Halemai ʻo Lu Daopei, hōʻike ka noiʻi i nā hopena hoʻohiki no nā maʻi, e hāʻawi ana i kahi koho ikaika i ka chemotherapy maʻamau.
I loko o kahi hoʻomohala hoihoi no Ka Lapaʻau ʻana i ka Maʻi ʻAʻai, Ua hōʻike ʻo BIOOCUS, me ka hui pū ʻana me ka Halemai ʻo Lu Daopei, i ka noiʻi hou loa e pili ana i ka hoʻohana ʻana o ka lāʻau lapaʻau CD7 chimeric antigen receptor (CAR) T-cell. ʻO kēia ʻano hana hou, e kuhikuhi ana i ka relapsed a refractory B-cell acute lymphoblastic leukemia (B-ALL) a me T-cell lymphoblastic lymphoma (T-LBL), e hōʻike ana i ka pono kiʻekiʻe a me ka palekana, e hoʻomaikaʻi nui ana i nā hopena o ka mea maʻi.
ʻO ke aʻo ʻana, i paʻi ʻia ma kahi puke pai hanohano, ua pili i kahi hoʻohālikelike like o nā maʻi e loaʻa ana i ka lāʻau lapaʻau CD7 CAR-T a ukali ʻia e ka hoʻohui ʻana me ka allogeneic hematopoietic stem cell transplantation (allo-HSCT) e kūʻē i ka poʻe i mālama ʻia me ka chemotherapy ma mua o ka hoʻoili ʻana. Hōʻike nā ʻike noiʻi ua like nā hopena ola lōʻihi o nā maʻi i loaʻa ka hoʻomaha piha (CR) me ka lāʻau lapaʻau CD7 CAR-T me ka poʻe i mālama ʻia me ka chemotherapy maʻamau. ʻO ka mea nui, ʻaʻole i loaʻa i ke aʻo ʻana ka piʻi nui ʻana o nā pilikia ma hope o ka transplant, e like me ka maʻi graft-versus-host (GVHD), nā maʻi, a i ʻole nā hanana ʻino ʻē aʻe.
ʻO nā mea koʻikoʻi o ke aʻo ʻana:
- Ka helu hoʻokuʻu piha: Ua hōʻike ka lāʻau lapaʻau CD7 CAR-T i kahi helu kala piha kupaianaha, me ka ʻoi aku o 97% o nā maʻi i pane maikaʻi i ka lāʻau lapaʻau.
- ʻIke Palekana: ʻOiai ke ʻano hana hou o ka hoʻohana ʻana i ka lāʻau lapaʻau CAR-T, ua ʻae maikaʻi ʻia ka lāʻau lapaʻau, me ka liʻiliʻi o nā hopena ʻaoʻao a ʻaʻohe piʻi nui o ka GVHD kiʻekiʻe a i ʻole nā pilikia koʻikoʻi ʻē aʻe.
- Holomua ma hope o ke kāpili ʻana: ʻO nā maʻi e hana ana i ka allo-HSCT ma hope o ka hoʻokō ʻana i ka CR me ka lāʻau CD7 CAR-T ua ʻike lākou i ke ola holoʻokoʻa (OS) a me ke ola ʻole o ka leukemia (LFS), hoʻohālikelike ʻia me nā lāʻau lapaʻau chemotherapy kuʻuna.
He hanana koʻikoʻi kēia noiʻi ma ke kahua o Ka lāʻau pale maʻi kanesa, e hāʻawi ana i ka manaʻolana no nā poʻe maʻi me nā ʻano leukemia a me lymphoma i hoʻihoʻi ʻia a i ʻole nā ʻano paʻakikī. Ke kūpaʻa nei ʻo BIOOCUS i ka hoʻolaha ʻana i nā palena o ka lāʻau lapaʻau CAR-T, e hāʻawi ana i nā hopena hou no nā poʻe maʻi i pau nā koho lapaʻau maʻamau. I ka wā e apo ai ka honua i kēia mau lāʻau lapaʻau ʻoi loa, aia ʻo BIOOCUS ma ke alo o ka hoʻomohala ʻana i nā lāʻau lapaʻau e lawe mai i ka loli maoli i nā hopena o ka mea maʻi.