Kugwira Ntchito Kwambiri kwa Chithandizo cha CD7 CAR-T pa Matenda a B-Cell: Kupita Patsogolo kwa Chithandizo cha Khansa
Kafukufuku waposachedwa akuwonetsa mphamvu ndi chitetezo cha chithandizo cha maselo a CD7 CAR-T pochiza khansa ya m'magazi ya B-cell acute lymphoblastic (B-ALL) yobwereranso kapena yokana matenda ndi T-cell lymphoblastic lymphoma (T-LBL). Kafukufukuyu, wochitidwa ndi BIOOCUS mogwirizana ndi Lu Daopei Hospital, akuwonetsa zotsatira zabwino kwa odwala, zomwe zikupereka njira ina yamphamvu m'malo mwa mankhwala ochiritsira achikhalidwe.
Mu chitukuko chosangalatsa cha Chithandizo cha Khansa, BIOOCUS, mogwirizana ndi Lu Daopei Hospital, yawulula kafukufuku wofunikira kwambiri pakugwiritsa ntchito chithandizo cha CD7 chimeric antigen receptor (CAR) T-cell. Njira yatsopanoyi, yolimbana ndi B-cell acute lymphoblastic leukemia (B-ALL) yobwereranso kapena yokana matenda ndi T-cell lymphoblastic lymphoma (T-LBL), ikuwonetsa kugwira ntchito bwino komanso chitetezo, zomwe zimathandizira kwambiri zotsatira za odwala.
Kafukufukuyu, wofalitsidwa mu magazini yotchuka, anali ndi kufananiza kofanana kwa odwala omwe amalandira chithandizo cha CD7 CAR-T kenako ndi kuphatikiza ndi allogeneic hematopoietic hematopoietic stem cell transplantation (allo-HSCT) motsutsana ndi omwe adalandira chithandizo cha chemotherapy asanapatsidwe. Zotsatira za kafukufukuyu zikuwonetsa kuti odwala omwe adapeza chikhululukiro chathunthu (CR) ndi chithandizo cha CD7 CAR-T anali ndi zotsatira zofanana za kupulumuka kwa nthawi yayitali ndi omwe adalandira chithandizo cha chemotherapy chachizolowezi. Chofunika kwambiri, kafukufukuyu sanapeze kuwonjezeka kwakukulu kwa mavuto omwe adachitika pambuyo pa kuikidwa kwa maselo, monga matenda a graft-versus-host (GVHD), matenda, kapena zochitika zina zoyipa.
Mfundo zazikulu za kafukufukuyu ndi izi:
- Chiwongola dzanja chonse: Chithandizo cha CD7 CAR-T chinawonetsa kuchuluka kwa kuchira kwathunthu, ndipo odwala opitilira 97% adayankha bwino chithandizocho.
- Mbiri Yachitetezo: Ngakhale kuti njira yatsopano yogwiritsira ntchito chithandizo cha CAR-T inalipo, chithandizocho chinali chovomerezeka bwino, ndipo zotsatira zake zinali zochepa ndipo palibe kuwonjezeka kwakukulu kwa GVHD yapamwamba kapena mavuto ena akuluakulu.
- Kupambana Pambuyo pa Kusamutsa Thupi: Odwala omwe adapatsidwa chithandizo cha allo-HSCT atalandira chithandizo cha CR ndi CD7 CAR-T adapulumuka bwino (OS) komanso popanda leukemia (LFS), mofanana ndi mankhwala achikhalidwe ochiritsira chemotherapy.
Kafukufukuyu akuyimira gawo lofunika kwambiri pa ntchito ya Chithandizo cha Khansa, kupereka chiyembekezo kwa odwala omwe ali ndi mitundu ina ya khansa ya m'magazi ndi lymphoma yomwe yabwereranso kapena yosachiritsika. BIOOCUS ikudziperekabe kupititsa patsogolo malire a chithandizo cha CAR-T, kupereka njira zatsopano kwa odwala omwe agwiritsa ntchito njira zamakono zochiritsira. Pamene dziko lapansi likulandira njira zamakonozi, BIOOCUS ili patsogolo pakupanga njira zochiritsira zomwe zimabweretsa kusintha kwenikweni kwa zotsatira za odwala.