Nūhou

Ma kahi hihia lapaʻau paionia, ua lanakila maikaʻi kahi maʻi 21 makahiki i nā pilikia o ka thalassemia ma o kahi lāʻau lapaʻau gene CRISPR holomua. Hōʻailona kēia ʻano hana hou i kahi hanana koʻikoʻi i ka mālama ʻana i nā maʻi koko koʻikoʻi e like me ka maʻi cell sickle (SCD) a me ka thalassemia.

Ma ka ʻaha kūkā ASH 2024 e hiki mai ana, e hōʻike ana ka hui lapaʻau o ka Halemai ʻo Lu Daopei i 13 mau ʻike noiʻi hou, e hōʻike ana i nā holomua i ka hematology a me ka hiki o ka lāʻau lapaʻau CAR-T, e hōʻoia hou ana i kā lākou kūpaʻa i ka hoʻomaikaʻi ʻana i nā hopena o ka mea maʻi.

Ma hope o ke kaua ʻana me ka lymphoma no ʻekolu mau makahiki, ua loaʻa i kahi wahine 61 makahiki ke kala piha ʻana ma o ka lāʻau lapaʻau CAR-T pālua hou ma BIOOCUS, e hōʻike ana i ka hiki ke hoʻololi i ke ola o nā lāʻau lapaʻau maʻi kanesa holomua.

Ke hoʻololi hou nei nā holomua hou i ka ʻenehana CRISPR/Cas i ke ʻano o ka hoʻoponopono ʻana i nā gene i ka noiʻi biomedical. Ke nānā nei kēia ʻatikala i kāna mau noi, e hōʻike ana i ka hiki ke mālama i nā maʻi genetic, nā maʻi ʻaʻai, a me nā maʻi lele.

Hōʻike kahi hihia kupaianaha ma BIOOCUS i ka hopena hoʻololi o ka lāʻau lapaʻau CD7 CAR-T i kahi keikikāne 15 makahiki me ka relapsed T-cell acute lymphoblastic leukemia (T-ALL), e alakaʻi ana i ke kala piha a me kahi hoʻoili lua kūleʻa.

Hauʻoli ʻo Bioocus e hui pū me ka 8th Immuno-Gene and Cell Therapy Congress (IGC 2024)! Ke kakali nei mākou i ka hana pū ʻana me nā loea honua a me ka ʻimi ʻana i nā hiʻohiʻona ʻoihana hou e kūlike me nā ʻenehana gene a me nā cell therapy hou loa. E hui pū kākou, e hoʻokumu i ka wā e hiki mai ana o ka immunotherapy.

Hōʻike kēia ʻatikala nūhou i ka noiʻi hou e pili ana i ka hoʻokele ʻana i nā ʻawaʻawa o ka lāʻau lapaʻau CAR-T no nā lymphomas B-cell. Hoʻoikaika ka haʻawina i nā hoʻolālā e lawelawe i nā hopena ʻaoʻao maʻamau e like me ka cytokine release syndrome (CRS) a me ka neurotoxicity (ICANS), e hōʻoiaʻiʻo ana i ka hoʻohana palekana ʻana i kēia lāʻau lapaʻau hou.

Hōʻike ka noiʻi hou loa i ka pono a me ka palekana o ka lāʻau lapaʻau CD7 CAR-T cell i ka mālama ʻana i ka relapsed a refractory B-cell acute lymphoblastic leukemia (B-ALL) a me T-cell lymphoblastic lymphoma (T-LBL). Hana ʻia e BIOOCUS me ka laulima ʻana me ka Halemai ʻo Lu Daopei, hōʻike ka noiʻi i nā hopena hoʻohiki no nā maʻi, e hāʻawi ana i kahi koho ikaika i ka chemotherapy maʻamau.

ʻO ke aʻo ʻana, i paʻi ʻia ma ka Ka Nūpepa o ka Oncology Lapaʻau, hōʻike i nā helu kala koʻikoʻi i nā poʻe maʻi i pau nā koho lapaʻau kuʻuna, e hōʻailona ana i kahi holomua hoʻohiki i ka mālama ʻana i ka maʻi kanesa.

Ua hōʻike ʻia kahi noiʻi hou i ka pono o ka lāʻau lapaʻau CD7 CAR-T i ukali ʻia e ka lua o ka allogeneic hematopoietic stem cell transplantation (HSCT) i nā poʻe maʻi me ka relapsed T-cell acute lymphoblastic leukemia (T-ALL) a me ka lymphoblastic lymphoma (LBL), e hōʻike ana i ka hiki ke hoʻokō i ka liʻiliʻi o ke koena o ka maʻi (MRD)-negative complete remission.

Hōʻike kahi haʻawina hou i ka holomua lōʻihi o ka lāʻau lapaʻau CD19 CAR T-cell i ka mālama ʻana i nā maʻi me ka relapsed/refractory acute lymphoblastic leukemia (ALL) ma hope o ka hoʻoili ʻana o nā cell stem hematopoietic allogeneic, e hāʻawi ana i ka manaʻolana hou i ka hematology.

Aia ʻo Bioocus ma ke alo o ka hoʻomohala ʻana i nā lāʻau lapaʻau CAR-T hanauna hou. ʻO ka puke hou a Kauka Chunrong Tong a me kāna hui ma ka Halemai ʻo Lu Daopei e hōʻike ana i nā holomua koʻikoʻi a me nā pilikia i ka hoʻohana ʻana i nā lāʻau lapaʻau CD19 CAR-T hanauna ʻelua i nā maʻi pediatric, e hōʻike ana i ka hoʻokō ʻana o Bioocus i ka mālama ʻana i ka maʻi kanesa hou.