Manaʻolana Hou no ka Chemotherapy-Refractory B-Cell Lymphoma: Hōʻike ka CAR-T Therapy i nā hopena hoʻohiki
Ua hōʻike ʻia e nā noiʻi hou ka hiki o ka Chimeric Antigen Receptor (CAR)-T cell therapy i ka mālama ʻana i nā maʻi me nā maʻi B-cell malignancies chemotherapy-refractory, ʻoi aku ka nui o ka diffuse. Lymphoma Pūnaewele B (DLBCL) a me nā lymphomas B-cell palaualelo. ʻO kēia haʻawina groundbreaking, i paʻi ʻia ma kaKa Nūpepa o ka Oncology Lapaʻau, hōʻike ʻia he hiki i ka lāʻau lapaʻau CAR-T ke lilo i holomua nui no nā poʻe maʻi i pau i nā koho lapaʻau kuʻuna.
Ma ke aʻo ʻana, ua loaʻa i kahi hui o 15 mau maʻi me nā maʻi ʻino B-cell holomua ka lāʻau lapaʻau CAR-T ma hope o ka loaʻa ʻana o kahi regimen chemotherapy conditioning. ʻO ka mea kupanaha, ua loaʻa i ka hapalua o kēia mau maʻi ke kala piha (CR), me ʻehā o nā maʻi ʻehiku i hiki ke loiloi ʻia me ka DLBCL chemotherapy-refractory. He mea hoʻohiki maikaʻi loa nā hopena, me kekahi mau maʻi e mālama ana i ka CR a hiki i 22 mau mahina.
Hana ka lāʻau lapaʻau CAR-T ma ka hoʻololi ʻana i nā pūnaewele T ponoʻī o ka mea maʻi e hōʻike i kahi mea loaʻa anti-CD19, a laila e kuhikuhi a luku i nā pūnaewele B kanesa. Ua ʻike ʻia ke aʻo ʻana ʻaʻole hiki ke hana wale ʻia kēia ʻano hana akā he mea kūpono hoʻi i ka hana ʻana i nā hoʻomaha mau loa. Eia nō naʻe, ʻaʻole i nele ka lāʻau lapaʻau i nā pilikia. Ua ʻike ʻia nā mea ʻawaʻawa koʻikoʻi, e like me ka cytokine release syndrome a me ka neurotoxicity, ʻoiai ua hiki ke hoʻokele ʻia a hoʻoponopono ʻia i loko o kekahi mau pule.
Ua hoʻokūpaʻa ʻo Kauka J. Kochenderfer, kekahi o nā mea noiʻi alakaʻi, i ke koʻikoʻi o kēia mau ʻike, me ka ʻōlelo ʻana, "ʻO kēia ka hōʻike mua o ka mālama pono ʻana o DLBCL me nā cell anti-CD19 CAR-T, a wehe ia i ka puka no ka hoʻomohala hou ʻana o kēia ʻano hana."
Hāʻawi nā ʻike o ke aʻo ʻana i ka manaʻolana hou no nā poʻe maʻi me nā lymphomas B-cell refractory, ka poʻe i loaʻa mua nā koho lapaʻau palena ʻole a me nā prognoses maikaʻi ʻole. I ka hoʻomau ʻana o ka ulu ʻana o ka CAR-T therapy, hiki paha ke lilo i lāʻau maʻamau no nā ʻano maʻi ʻino B-cell like ʻole, e hāʻawi ana i kahi laina ola i ka poʻe e hakakā nei i kēia mau maʻi kanesa ʻino.