Ithemba Elitsha leChemotherapy-Refractory B-Cell Lymphoma: Unyango lweCAR-T lubonisa iziphumo ezithembisayo
Uphando lwakutshanje lubonise amandla onyango lweeseli ze-Chimeric Antigen Receptor (CAR)-T ekunyangeni izigulana ezine-chemotherapy-refractory B-cell malignancies, ingakumbi i-diffuse large diffuse I-B-Cell Lymphoma (DLBCL) kunye nee-lymphomas ze-B-cell ezingasebenziyo. Olu phononongo oluphambili, olupapashwe kwiIjenali ye-Clinical Oncology, icebisa ukuba unyango lwe-CAR-T lunokuba yimpumelelo enkulu kwizigulane eziye zasebenzisa iindlela zonyango zemveli.
Kolu phononongo, iqela lezigulana ezili-15 ezine-B-cell malignancies eziphucukileyo lenze unyango lwe-CAR-T emva kokufumana unyango lwe-chemotherapy. Okumangalisayo kukuba, ngaphezu kwesiqingatha sezi zigulana zifumene i-complete remission (CR), kuquka nezigulana ezine kwezisixhenxe ezivavanyiweyo ezine-chemotherapy-refractory DLBCL. Iziphumo zithembisa kakhulu, ezinye izigulana zigcina i-CR ukuya kuthi ga kwiinyanga ezingama-22.
Unyango lwe-CAR-T lusebenza ngokuguqula iiseli ze-T zesigulana ngokwemfuza ukuze ziveze i-anti-CD19 receptor, ethi emva koko ijolise kwaye itshabalalise iiseli ze-B ezinomhlaza. Olu phononongo luphawule ukuba le ndlela yayingapheleli nje ekuphuhliseni ukukhululwa okuhlala ixesha elide. Nangona kunjalo, unyango belunemingeni. Izinto ezinobungozi obuqatha, ezifana ne-cytokine release syndrome kunye ne-neurotoxicity, zaphawulwa, nangona ezi ngokubanzi zazilawuleka kwaye zisonjululwe kwiiveki ezimbalwa.
UGqr. J. Kochenderfer, omnye wabaphandi abaphambili, ugxininise ukubaluleka kwezi ziphumo, esithi, "Le yingxelo yokuqala yonyango oluphumeleleyo lwe-DLBCL ngeeseli ze-anti-CD19 CAR-T, kwaye ivula ithuba lokuphuhliswa ngakumbi kwale ndlela."
Iziphumo zophando zinika ithemba elitsha kwizigulana ezine-refractory B-cell lymphomas, ezazineendlela ezimbalwa zonyango kunye neziphumo ezibi zokuqikelela. Njengoko unyango lwe-CAR-T luqhubeka lukhula, lunokuba lunyango oluqhelekileyo lweentlobo ngeentlobo ze-B-cell monicancies, olubonelela ngoncedo kwabo balwa nale mihlaza inamandla.