Icyizere Gishya ku Buvuzi bwa Chimiotherapie-Refractory B-Cell Lymphoma: Ubuvuzi bwa CAR-T bwagaragaje umusaruro mwiza
Ubushakashatsi buherutse bwerekanye ubushobozi bwa Chimeric Antigen Receptor (CAR)-T selile mu kuvura abarwayi bafite kanseri ya B-cells iterwa na chemotherapy, cyane cyane kanseri nini ikwirakwira mu bantu. Lymphoma y'uturemangingo twa B (DLBCL) na limfoma ya B-cell indolent. Ubu bushakashatsi bw'ibanze, bwasohotse muIkinyamakuru cy'ubuvuzi bwa kanseri, bigaragaza ko uburyo bwo kuvura bwa CAR-T bushobora kuba ingirakamaro ku barwayi barangije uburyo bwabo bwo kuvura gakondo.
Muri ubwo bushakashatsi, itsinda ry’abarwayi 15 bafite kanseri yo mu bwoko bwa B-cell bakorewe ubuvuzi bwa CAR-T nyuma yo guhabwa imiti ya chimiotherapie. Igitangaje ni uko abarenga kimwe cya kabiri cy’aba barwayi bakize burundu (CR), harimo bane kuri barindwi bapimwe bafite DLBCL idakira imiti ya chimiotherapie. Ibisubizo biratanga icyizere cyane, aho bamwe mu barwayi bagumana CR mu gihe cy’amezi 22.
Ubuvuzi bwa CAR-T bukora mu guhindura uturemangingo twa T tw’umurwayi kugira ngo tugaragaze anti-CD19 receptor, hanyuma ikaba yibasira ikanasenya uturemangingo twa B twa kanseri. Ubushakashatsi bwagaragaje ko ubu buryo butashobokaga gusa ahubwo bwari bufite akamaro kanini mu gutuma habaho kugabanuka kw’uturemangingo mu buryo burambye. Ariko, ubu buvuzi ntibwari bubuzemo imbogamizi. Uburozi bukomeye, nka cytokine release syndrome na neurotoxicity, bwagaragaye, nubwo muri rusange ibi byashoboraga gukemuka kandi bigakemuka mu byumweru bike.
Dr. J. Kochenderfer, umwe mu bashakashatsi bakuru, yashimangiye akamaro k'ibi byavuye mu bushakashatsi, agira ati: "Iyi ni raporo ya mbere igaragaza uburyo DLBCL yavuwe neza hakoreshejwe uturemangingo twa CAR-T turwanya CD19, kandi bifungura amarembo yo gukomeza iterambere ry'ubu buryo."
Ibyavuye mu bushakashatsi bitanga icyizere gishya ku barwayi ba kanseri ya B-cell lymphoma idashobora kuvura, mbere bari bafite uburyo buke bwo kuyivura no kuba badashobora kuyivura neza. Uko ubuvuzi bwa CAR-T bukomeza gutera imbere, bushobora kuba uburyo busanzwe bwo kuvura kanseri zitandukanye za B-cell, bugatanga ubufasha ku barwayi barwaye kanseri zikomeye.