Tariro Itsva yeChemotherapy-Refractory B-Cell Lymphoma: Kurapa kweCAR-T Kunoratidza Mhedzisiro Inofadza
Ongororo dzichangobva kuitwa dzakaratidza kugona kweChimeric Antigen Receptor (CAR)-T cell therapy mukurapa varwere vane chemotherapy-refractory B-cell malignancies, kunyanya diffuse large B-Cell Lymphoma (DLBCL) uye maB-cell lymphomas asina simba. Chidzidzo ichi chinoshamisa, chakaburitswa muChinyorwa cheClinical Oncology, zvinoratidza kuti kurapwa kweCAR-T kunogona kuva budiriro huru kune varwere vakapedza nzira dzekurapa dzechinyakare.
Muchidzidzo ichi, boka revanhu gumi nevashanu vane kenza yeB-cell yakakwira vakarapwa neCAR-T mushure mekurapwa nechemotherapy. Zvinoshamisa kuti, vanopfuura hafu yevarwere ava vakawana relievement yakakwana (CR), kusanganisira vana pavarwere vanomwe vakaongororwa vane DLBCL isingarapike nechemotherapy. Mhedzisiro yacho inonyatsovimbisa, vamwe varwere vachiramba vaine CR kwemwedzi inosvika makumi maviri nemiviri.
Kurapa kweCAR-T kunoshanda nekuchinja majini emasero eT emurwere kuti abudise anti-CD19 receptor, iyo inobva yananga nekuparadza masero eB ane kenza. Chidzidzo ichi chakaona kuti nzira iyi yaisangogoneka chete asiwo yaishanda zvikuru mukugadzira relievers dzinogara kwenguva refu. Zvisinei, kurapwa kwacho kwaive nematambudziko. Zvirwere zvine chepfu zvakanyanya, zvakaita se cytokine release syndrome uye neurotoxicity, zvakaonekwa, kunyange zvazvo izvi zvaiwanzogoneka uye zvakagadziriswa mukati memavhiki mashoma.
Dr. J. Kochenderfer, mumwe wevaongorori vakuru, akasimbisa kukosha kwezviwanikwa izvi, achiti, "Uyu ndiwo mushumo wekutanga wekubudirira kwekurapa DLBCL nemasero ekurwisa CD19 CAR-T, uye zvinovhura mukana wekufambira mberi kwenzira iyi."
Zvakawanikwa muchidzidzo ichi zvinopa tariro itsva kuvarwere vane refractory B-cell lymphomas, avo vaimbova nesarudzo shoma dzekurapa uye fungidziro dzisina kunaka. Sezvo kurapwa kweCAR-T kuri kuramba kuchichinja, kunogona kuve kurapwa kwakajairika kwezvirwere zvakasiyana-siyana zveB-cell, zvichipa rubatsiro kune avo vari kurwisa kenza idzi dzine simba.