Ithemba Elisha Le-Chemotherapy-Refractory B-Cell Lymphoma: Ukwelashwa Kwe-CAR-T Kubonisa Imiphumela Ethembisayo
Ucwaningo lwakamuva luveze amandla okwelashwa kwamaseli e-Chimeric Antigen Receptor (CAR)-T ekwelapheni iziguli ezine-chemotherapy-refractory B-cell monitors, ikakhulukazi ezisakazeka kakhulu. I-B-Cell Lymphoma (DLBCL) kanye nama-lymphoma e-B-cell angasebenzi. Lolu cwaningo oluqavile, olushicilelwe ku-Ijenali ye-Clinical Oncology, kusikisela ukuthi ukwelashwa kwe-CAR-T kungaba yintuthuko ebalulekile ezigulini eseziqede izindlela zokwelapha zendabuko.
Kulolu cwaningo, iqembu leziguli ezingu-15 ezine-B-cell monoancies ezithuthukile lenziwa ukwelashwa kwe-CAR-T ngemuva kokuthola uhlelo lwe-chemotherapy olulungisa isimo. Okuphawulekayo ukuthi, ngaphezu kwengxenye yalezi ziguli zithole ukuxolelwa okuphelele (CR), okuhlanganisa neziguli ezine kweziyisikhombisa ezihlolwe ezine-DLBCL engahambisani ne-chemotherapy. Imiphumela iyathembisa kakhulu, kanti ezinye iziguli zigcina i-CR izinyanga ezingafika kwezingu-22.
Ukwelashwa kwe-CAR-T kusebenza ngokuguqula izakhi zofuzo zamaseli e-T esiguli ukuze kuvele i-anti-CD19 receptor, ehlasela futhi ibhubhise amaseli e-B anomdlavuza. Ucwaningo luphawule ukuthi le ndlela yayingagcini nje ngokuba nokwenzeka kodwa futhi yayisebenza kahle kakhulu ekukhiqizeni ukukhululwa okuhlala isikhathi eside. Kodwa-ke, ukwelashwa kwakunezinselele. Ubuthi obuyingozi, njenge-cytokine release syndrome kanye ne-neurotoxicity, kwaphawulwa, yize lokhu ngokuvamile kwakulula ukukuphatha futhi kwaxazululwa phakathi namasonto ambalwa.
UDkt. J. Kochenderfer, omunye wabacwaningi abaphambili, ugcizelele ukubaluleka kwalokhu okutholakele, ethi, "Lona umbiko wokuqala wokwelashwa okuphumelelayo kwe-DLBCL ngamaseli e-anti-CD19 CAR-T, futhi kuvula ithuba lokuthuthuka okwengeziwe kwale ndlela."
Okutholakele kocwaningo kunikeza ithemba elivuselelwe ezigulini ezine-B-cell lymphomas ezingaphili kahle, ezazinezinketho zokwelashwa ezilinganiselwe kanye nezibikezelo ezimbi. Njengoba ukwelashwa kwe-CAR-T kuqhubeka nokukhula, kungaba ukwelashwa okujwayelekile kwezinhlobo ezahlukene zomdlavuza we-B-cell, okuhlinzeka ngosizo kulabo abalwa nalezi zimdlavuza ezinamandla.