Chiyembekezo Chatsopano cha Chemotherapy-Refractory B-Cell Lymphoma: Chithandizo cha CAR-T Chikuwonetsa Zotsatira Zabwino

Kafukufuku waposachedwapa wasonyeza kuthekera kwa chithandizo cha maselo a Chimeric Antigen Receptor (CAR)-T pochiza odwala omwe ali ndi khansa ya B-cell yomwe siigwirizana ndi chemotherapy, makamaka khansa yayikulu yofalikira. B-Cell Lymphoma (DLBCL) ndi ma B-cell lymphomas osagwira ntchito. Kafukufuku wodabwitsa uyu, wofalitsidwa muMagazini ya Clinical Oncology, akusonyeza kuti chithandizo cha CAR-T chingakhale chitukuko chofunikira kwa odwala omwe agwiritsa ntchito njira zochiritsira zachikhalidwe.

Mu kafukufukuyu, gulu la odwala 15 omwe ali ndi khansa ya B-cell yotsogola adalandira chithandizo cha CAR-T atalandira chithandizo cha chemotherapy. Chodabwitsa n'chakuti, oposa theka la odwalawa adapeza chikhululukiro chonse (CR), kuphatikizapo odwala anayi mwa asanu ndi awiri omwe adayesedwa omwe ali ndi DLBCL yosachiritsika ndi chemotherapy. Zotsatira zake ndi zabwino kwambiri, ndipo odwala ena amakhalabe ndi CR kwa miyezi 22.

Chithandizo cha CAR-T chimagwira ntchito posintha majini a maselo a T a wodwala kuti apereke anti-CD19 receptor, yomwe kenako imalimbana ndi kuwononga maselo a B omwe ali ndi khansa. Kafukufukuyu adawona kuti njira imeneyi sinali yotheka kokha komanso yothandiza kwambiri popanga ma relieves okhazikika. Komabe, chithandizocho sichinali chopanda mavuto. Mavuto oopsa, monga cytokine release syndrome ndi neurotoxicity, adadziwika, ngakhale kuti nthawi zambiri izi zinkatha kuthetsedwa mkati mwa milungu ingapo.

Dr. J. Kochenderfer, m'modzi mwa ofufuza otsogola, adagogomezera kufunika kwa zomwe zapezekazi, nati, "Ili ndi lipoti loyamba la chithandizo chabwino cha DLBCL ndi maselo oletsa CD19 CAR-T, ndipo limatsegula chitseko cha kupita patsogolo kwa njira iyi."

Zomwe zapezeka mu kafukufukuyu zapereka chiyembekezo chatsopano kwa odwala omwe ali ndi matenda a B-cell lymphomas, omwe kale anali ndi njira zochepa zochiritsira komanso matenda osachiritsika. Pamene chithandizo cha CAR-T chikupitirirabe kusintha, chikhoza kukhala chithandizo chokhazikika cha khansa zosiyanasiyana za B-cell, zomwe zingathandize anthu omwe akulimbana ndi khansa yoopsayi.